Long-Term Outcomes of Patients With Spinal Cord Gliomas Treated by Modern Conformal Radiation Techniques

Journal Article · Thu Sep 01 00:00:00 EDT 2011 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2010.05.009· OSTI ID:21587710

Kahn, Jenna; Loeffler, Jay Steven; Niemierko, Andrzej ^[1]; Chiocca, E Antonio ^[2]; Batchelor, Tracy ^[3]; Chakravarti, Arnab ^[2]

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1. Department of Radiation Oncology, Massachusetts General Hospital/Harvard Medical School, Boston, MA (United States)
2. James Cancer Hospital/Solove Research Institute, Ohio State University Medical Center, Department of Neurological Surgery, Columbus, OH (United States)
3. Massachusetts General Hospital/Harvard Medical School, Department of Neuro-Oncology, Boston, MA (United States)

Purpose: This study retrospectively examines the long-term therapeutic outcomes of 32 patients with primary spinal cord gliomas at Massachusetts General Hospital between 1991 and 2005 treated by either photon intensity-modulated radiotherapy or conformal proton radiotherapy. Methods and Materials: Individual patient tumor types included 14 ependymomas, 17 astrocytomas, and one oligodendroglioma. Twenty-two patients were treated with photon beam radiation therapy, and 10 patients were treated with proton beam therapy. The overall survival and time to progression were analyzed. Average radiation dose for patients was 51 Gy in 1.8 median daily fractions over 29 treatments. Results: For all 32 patients, the overall 5-year survival was 65% and the progression-free survival was 61%, respectively. Overall survival was significantly worse for patients more than 55 years of age (p = 0.02). Ependymoma patients had significantly longer survival times than astrocytoma patients (p = 0.05). Patients who had undergone a biopsy developed worse outcomes then those with a resection (p = 0.05). With the caveat of a limited number of patients, the multivariate model seems to suggest improved overall survival for younger patients (<54 years of age), ependymoma histology, and photon vs. proton treatment. Conclusion: For patients with spinal cord gliomas, significant factors associated with patient outcome include tumor pathology, age, extent of surgery, and treatment.

• OSTI ID: 21587710
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Vol. 81, Issue 1; Other Information: DOI: 10.1016/j.ijrobp.2010.05.009; PII: S0360-3016(10)00681-4; Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ASTROCYTOMAS
BIOPSY
HISTOLOGY
MULTIVARIATE ANALYSIS
PATHOLOGY
PHOTON BEAMS
PHOTONS
PROTON BEAMS
RADIATION DOSES
RADIOTHERAPY
SPINAL CORD
SURGERY
BEAMS
BOSONS
CENTRAL NERVOUS SYSTEM
DIAGNOSTIC TECHNIQUES
DISEASES
DOSES
ELEMENTARY PARTICLES
GLIOMAS
MASSLESS PARTICLES
MATHEMATICS
MEDICINE
NEOPLASMS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NUCLEAR MEDICINE
NUCLEON BEAMS
PARTICLE BEAMS
RADIOLOGY
STATISTICS
THERAPY