Role of curcumin-dependent modulation of tumor microenvironment of a murine T cell lymphoma in altered regulation of tumor cell survival

Journal Article · Sun May 01 00:00:00 EDT 2011 · Toxicology and Applied Pharmacology

DOI:https://doi.org/10.1016/j.taap.2011.03.002· OSTI ID:21535288

Vishvakarma, Naveen Kumar; Kumar, Anjani

Using a murine model of a T cell lymphoma, in the present study, we report that tumor growth retarding action of curcumin involves modulation of some crucial parameters of tumor microenvironment regulating tumor progression. Curcumin-administration to tumor-bearing host caused an altered pH regulation in tumor cells associated with alteration in expression of cell survival and apoptosis regulatory proteins and genes. Nevertheless, an alteration was also observed in biophysical parameters of tumor microenvironment responsible for modulation of tumor growth pertaining to hypoxia, tumor acidosis, and glucose metabolism. The study thus sheds new light with respect to the antineoplastic action of curcumin against a tumor-bearing host with progressively growing tumor of hematological origin. This will help in optimizing application of the drug and anticancer research and therapy. - Graphical Abstract: Display Omitted

• OSTI ID: 21535288
• Journal Information: Toxicology and Applied Pharmacology, Vol. 252, Issue 3; Other Information: DOI: 10.1016/j.taap.2011.03.002; PII: S0041-008X(11)00088-3; Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; ISSN 0041-008X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
APOPTOSIS
CURCUMIN
DRUGS
GENES
GLUCOSE
GROWTH
LYMPHOMAS
METABOLISM
MODULATION
THERAPY
TUMOR CELLS
ALDEHYDES
ANIMAL CELLS
AROMATICS
CARBOHYDRATES
DISEASES
DYES
ETHERS
HEXOSES
HYDROXY COMPOUNDS
IMMUNE SYSTEM DISEASES
KETONES
MEDICINE
MONOSACCHARIDES
NEOPLASMS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PHENOLS
POLYPHENOLS
SACCHARIDES