Irradiation Design for an Experimental Murine Model

Journal Article · Tue Dec 07 00:00:00 EST 2010 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.3531598· OSTI ID:21506972

Ballesteros-Zebadua, P; Moreno-Jimenez, S; Suarez-Campos, J E; Celis, M A ^[1]; Larraga-Gutierrez, J M; Garcia-Garduno, O A ^[2]; Custodio-Ramirez, V; Paz, C ^[3]

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1. Unidad de Radiocirugia, Instituto Nacional de Neurologia y Neurocirugia Insurgentes Sur 3677. Col. La Fama, C.P. 14269, Tlalpan, Mexico, D.F. (Mexico)
2. Laboratorio de Fisica Medica, Instituto Nacional de Neurologia y Neurocirugia Insurgentes Sur 3677. Col. La Fama, C.P. 14269, Tlalpan, Mexico, D.F. (Mexico)
3. Laboratorio de Neurofisiologia, Instituto Nacional de Neurologia y Neurocirugia Insurgentes Sur 3677. Col. La Fama, C.P. 14269, Tlalpan, Mexico, D.F. (Mexico)

In radiotherapy and stereotactic radiosurgery, small animal experimental models are frequently used, since there are still a lot of unsolved questions about the biological and biochemical effects of ionizing radiation. This work presents a method for small-animal brain radiotherapy compatible with a dedicated 6MV Linac. This rodent model is focused on the research of the inflammatory effects produced by ionizing radiation in the brain. In this work comparisons between Pencil Beam and Monte Carlo techniques, were used in order to evaluate accuracy of the calculated dose using a commercial planning system. Challenges in this murine model are discussed.

• OSTI ID: 21506972
• Journal Information: AIP Conference Proceedings, Vol. 1310, Issue 1; Conference: 11. Mexican symposium on medical physics, Mexico City (Mexico), 19-22 Mar 2010; Other Information: DOI: 10.1063/1.3531598; (c) 2010 American Institute of Physics; ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS
ACCURACY
BEAMS
BRAIN
COMPARATIVE EVALUATIONS
COMPUTERIZED SIMULATION
DESIGN
DOSIMETRY
INFLAMMATION
IONIZATION
IONIZING RADIATIONS
LABORATORY ANIMALS
LINEAR ACCELERATORS
MONTE CARLO METHOD
PLANNING
RADIOTHERAPY
RODENTS
SURGERY
TOMOGRAPHY
ACCELERATORS
ANIMALS
BODY
CALCULATION METHODS
CENTRAL NERVOUS SYSTEM
DIAGNOSTIC TECHNIQUES
EVALUATION
MAMMALS
MEDICINE
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANS
PATHOLOGICAL CHANGES
RADIATIONS
RADIOLOGY
SIMULATION
SYMPTOMS
THERAPY
VERTEBRATES