Solubility and release of fenbufen intercalated in Mg, Al and Mg, Al, Fe layered double hydroxides (LDH): The effect of Eudragit S 100 covering
- GIR-QUESCAT, Departamento de Quimica Inorganica, Universidad de Salamanca, 37008 Salamanca (Spain)
Following different preparation routes, fenbufen has been intercalated in the interlayer space of layered double hydroxides with Mg{sup 2+} and Al{sup 3+} or Mg{sup 2+}, Al{sup 3+} and Fe{sup 3+} in the layers. Well crystallized samples were obtained in most of the cases (intercalation was not observed by reconstruction of the MgAlFe matrix), with layer heights ranging between 16.1 and 18.8 A. The presence of the LDH increases the solubility of fenbufen, especially when used as a matrix. The dissolution rate of the drug decreases when the drug is intercalated, and is even lower in those systems containing iron; release takes place through ionic exchange with phosphate anions from the solution. Preparation of microspheres with Eudragit S 100 leads to solids with an homogeneous, smooth surface with efficient covering of the LDH surface, as drug release was not observed at pH lower than 7. - Graphical abstract: LDHs containing Mg, Al, Fe increase fenbufen solubility, release takes place through ionic exchange with phosphate anions from the medium. Spherical solids with homogeneous, smooth surface are formed when using Eudragit S 100, efficiently covering the LDH surface. Display Omitted
- OSTI ID:
- 21504032
- Journal Information:
- Journal of Solid State Chemistry, Vol. 183, Issue 12; Other Information: DOI: 10.1016/j.jssc.2010.10.017; PII: S0022-4596(10)00471-8; Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; ISSN 0022-4596
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
ALUMINIUM HYDROXIDES
ALUMINIUM IONS
CLATHRATES
DISSOLUTION
DRUGS
ION EXCHANGE
IRON HYDROXIDES
IRON IONS
LAYERS
MAGNESIUM HYDROXIDES
MAGNESIUM IONS
MICROSPHERES
PH VALUE
PHOSPHATES
SOLUBILITY
ALKALINE EARTH METAL COMPOUNDS
ALUMINIUM COMPOUNDS
CHARGED PARTICLES
HYDROGEN COMPOUNDS
HYDROXIDES
IONS
IRON COMPOUNDS
MAGNESIUM COMPOUNDS
OXYGEN COMPOUNDS
PHOSPHORUS COMPOUNDS
TRANSITION ELEMENT COMPOUNDS