skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Radiotherapy for Esthesioneuroblastoma: Is Elective Nodal Irradiation Warranted in the Multimodality Treatment Approach?

Abstract

Purpose: The role of elective nodal irradiation (ENI) in radiotherapy for esthesioneuroblastoma (ENB) has not been clearly defined. We analyzed treatment outcomes of patients with ENB and the frequency of cervical nodal failure in the absence of ENI. Methods and Materials: Between August 1996 and December 2007, we consulted with 19 patients with ENB regarding radiotherapy. Initial treatment consisted of surgery alone in 2 patients; surgery and postoperative radiotherapy in 4; surgery and adjuvant chemotherapy in 1; surgery, postoperative radiotherapy, and chemotherapy in 3; and chemotherapy followed by radiotherapy or concurrent chemoradiotherapy in 5. Five patients did not receive planned radiotherapy because of disease progression. Including 2 patients who received salvage radiotherapy, 14 patients were treated with radiotherapy. Elective nodal irradiation was performed in 4 patients with high-risk factors, including 3 with cervical lymph node metastasis at presentation. Results: Fourteen patients were analyzable, with a median follow-up of 27 months (range, 7-64 months). The overall 3-year survival rate was 73.4%. Local failure occurred in 3 patients (21.4%), regional cervical failure in 3 (21.4%), and distant failure in 2 (14.3%). No cervical nodal failure occurred in patients treated with combined systemic chemotherapy regardless of ENI. Three cervical failures occurred in themore » 4 patients treated with ENI or neck dissection (75%), none of whom received systemic chemotherapy. Conclusions: ENI during radiotherapy for ENB seems to play a limited role in preventing cervical nodal failure. Omitting ENI may be an option if patients are treated with a combination of radiotherapy and chemotherapy.« less

Authors:
;  [1];  [2];  [3];  [4];  [5]; ; ; ;  [1]
  1. Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of)
  2. Department of Medical Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of)
  3. Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of)
  4. Department of Neurosurgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of)
  5. Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of)
Publication Date:
OSTI Identifier:
21491583
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 79; Journal Issue: 2; Other Information: DOI: 10.1016/j.ijrobp.2009.10.067; PII: S0360-3016(09)03552-4; Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CHEMOTHERAPY; EPITHELIUM; FAILURES; LYMPH NODES; METASTASES; NOSE; RADIOTHERAPY; SURGERY; ANIMAL TISSUES; BODY; FACE; HEAD; LYMPHATIC SYSTEM; MEDICINE; NUCLEAR MEDICINE; RADIOLOGY; RESPIRATORY SYSTEM; THERAPY

Citation Formats

Noh, O Kyu, Lee, Sang-wook, Yoon, Sang Min, E-mail: drsmyoon@amc.seoul.k, Kim, Sung Bae, Kim, Sang Yoon, Kim, Chang Jin, Jo, Kyung Ja, Choi, Eun Kyung, Song, Si Yeol, Kim, Jong Hoon, and Ahn, Seung Do. Radiotherapy for Esthesioneuroblastoma: Is Elective Nodal Irradiation Warranted in the Multimodality Treatment Approach?. United States: N. p., 2011. Web. doi:10.1016/j.ijrobp.2009.10.067.
Noh, O Kyu, Lee, Sang-wook, Yoon, Sang Min, E-mail: drsmyoon@amc.seoul.k, Kim, Sung Bae, Kim, Sang Yoon, Kim, Chang Jin, Jo, Kyung Ja, Choi, Eun Kyung, Song, Si Yeol, Kim, Jong Hoon, & Ahn, Seung Do. Radiotherapy for Esthesioneuroblastoma: Is Elective Nodal Irradiation Warranted in the Multimodality Treatment Approach?. United States. https://doi.org/10.1016/j.ijrobp.2009.10.067
Noh, O Kyu, Lee, Sang-wook, Yoon, Sang Min, E-mail: drsmyoon@amc.seoul.k, Kim, Sung Bae, Kim, Sang Yoon, Kim, Chang Jin, Jo, Kyung Ja, Choi, Eun Kyung, Song, Si Yeol, Kim, Jong Hoon, and Ahn, Seung Do. 2011. "Radiotherapy for Esthesioneuroblastoma: Is Elective Nodal Irradiation Warranted in the Multimodality Treatment Approach?". United States. https://doi.org/10.1016/j.ijrobp.2009.10.067.
@article{osti_21491583,
title = {Radiotherapy for Esthesioneuroblastoma: Is Elective Nodal Irradiation Warranted in the Multimodality Treatment Approach?},
author = {Noh, O Kyu and Lee, Sang-wook and Yoon, Sang Min, E-mail: drsmyoon@amc.seoul.k and Kim, Sung Bae and Kim, Sang Yoon and Kim, Chang Jin and Jo, Kyung Ja and Choi, Eun Kyung and Song, Si Yeol and Kim, Jong Hoon and Ahn, Seung Do},
abstractNote = {Purpose: The role of elective nodal irradiation (ENI) in radiotherapy for esthesioneuroblastoma (ENB) has not been clearly defined. We analyzed treatment outcomes of patients with ENB and the frequency of cervical nodal failure in the absence of ENI. Methods and Materials: Between August 1996 and December 2007, we consulted with 19 patients with ENB regarding radiotherapy. Initial treatment consisted of surgery alone in 2 patients; surgery and postoperative radiotherapy in 4; surgery and adjuvant chemotherapy in 1; surgery, postoperative radiotherapy, and chemotherapy in 3; and chemotherapy followed by radiotherapy or concurrent chemoradiotherapy in 5. Five patients did not receive planned radiotherapy because of disease progression. Including 2 patients who received salvage radiotherapy, 14 patients were treated with radiotherapy. Elective nodal irradiation was performed in 4 patients with high-risk factors, including 3 with cervical lymph node metastasis at presentation. Results: Fourteen patients were analyzable, with a median follow-up of 27 months (range, 7-64 months). The overall 3-year survival rate was 73.4%. Local failure occurred in 3 patients (21.4%), regional cervical failure in 3 (21.4%), and distant failure in 2 (14.3%). No cervical nodal failure occurred in patients treated with combined systemic chemotherapy regardless of ENI. Three cervical failures occurred in the 4 patients treated with ENI or neck dissection (75%), none of whom received systemic chemotherapy. Conclusions: ENI during radiotherapy for ENB seems to play a limited role in preventing cervical nodal failure. Omitting ENI may be an option if patients are treated with a combination of radiotherapy and chemotherapy.},
doi = {10.1016/j.ijrobp.2009.10.067},
url = {https://www.osti.gov/biblio/21491583}, journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 2,
volume = 79,
place = {United States},
year = {Tue Feb 01 00:00:00 EST 2011},
month = {Tue Feb 01 00:00:00 EST 2011}
}