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Title: Nanoparticles as contrast-enhancing agents in optical coherence tomography imaging of the structural components of skin: Quantitative evaluation

Abstract

This work examines the effect of gold nanoshells and titania nanoparticles on the imaging contrast of structural components of skin in optical coherence tomography (OCT). Experimental data are compared to Monte Carlo (MC) simulation results. In experiments with pig skin in vivo, the epidermis - dermis contrast is improved from 0.78 {+-} 0.03 to 0.92 {+-} 0.04 by gold nanoshells applied to the skin surface and from 0.78 {+-} 0.03 to 0.86 {+-} 0.04 by titania nanoparticles. The contrast of glands is enhanced by titania from 0.68 {+-} 0.12 to 0.84 {+-} 0.07. The highest contrast is reached 120 - 150 min after applying gold nanoshells and 160 - 200 min after applying titania. According to the MC simulation results, the contrast of inclusions increases from zero to 0.85 and 0.65, respectively. (optical tomography)

Authors:
; ;  [1]; ; ;  [2]
  1. Institute of Applied Physics, Russian Academy of Sciences, Nizhnii Novgorod (Russian Federation)
  2. Nizhnii Novgorod State Medical Academy, Nizhnii Novgorod (Russian Federation)
Publication Date:
OSTI Identifier:
21471340
Resource Type:
Journal Article
Journal Name:
Quantum Electronics (Woodbury, N.Y.)
Additional Journal Information:
Journal Volume: 40; Journal Issue: 6; Other Information: DOI: 10.1070/QE2010v040n06ABEH014294; Journal ID: ISSN 1063-7818
Country of Publication:
United States
Language:
English
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY; EPIDERMIS; EXPERIMENTAL DATA; GLANDS; GOLD; IN VIVO; MONTE CARLO METHOD; NANOSTRUCTURES; SIMULATION; SURFACES; SWINE; TITANIUM OXIDES; TOMOGRAPHY; ANIMAL TISSUES; ANIMALS; BODY; CALCULATION METHODS; CHALCOGENIDES; DATA; DIAGNOSTIC TECHNIQUES; DOMESTIC ANIMALS; ELEMENTS; EPITHELIUM; INFORMATION; MAMMALS; METALS; NUMERICAL DATA; ORGANS; OXIDES; OXYGEN COMPOUNDS; SKIN; TITANIUM COMPOUNDS; TRANSITION ELEMENT COMPOUNDS; TRANSITION ELEMENTS; VERTEBRATES

Citation Formats

Kirillin, M Yu, Agrba, P D, Kamenskii, V A, Sirotkina, M A, Shiryamova, M V, and Zagainova, E V. Nanoparticles as contrast-enhancing agents in optical coherence tomography imaging of the structural components of skin: Quantitative evaluation. United States: N. p., 2010. Web. doi:10.1070/QE2010V040N06ABEH014294.
Kirillin, M Yu, Agrba, P D, Kamenskii, V A, Sirotkina, M A, Shiryamova, M V, & Zagainova, E V. Nanoparticles as contrast-enhancing agents in optical coherence tomography imaging of the structural components of skin: Quantitative evaluation. United States. https://doi.org/10.1070/QE2010V040N06ABEH014294
Kirillin, M Yu, Agrba, P D, Kamenskii, V A, Sirotkina, M A, Shiryamova, M V, and Zagainova, E V. 2010. "Nanoparticles as contrast-enhancing agents in optical coherence tomography imaging of the structural components of skin: Quantitative evaluation". United States. https://doi.org/10.1070/QE2010V040N06ABEH014294.
@article{osti_21471340,
title = {Nanoparticles as contrast-enhancing agents in optical coherence tomography imaging of the structural components of skin: Quantitative evaluation},
author = {Kirillin, M Yu and Agrba, P D and Kamenskii, V A and Sirotkina, M A and Shiryamova, M V and Zagainova, E V},
abstractNote = {This work examines the effect of gold nanoshells and titania nanoparticles on the imaging contrast of structural components of skin in optical coherence tomography (OCT). Experimental data are compared to Monte Carlo (MC) simulation results. In experiments with pig skin in vivo, the epidermis - dermis contrast is improved from 0.78 {+-} 0.03 to 0.92 {+-} 0.04 by gold nanoshells applied to the skin surface and from 0.78 {+-} 0.03 to 0.86 {+-} 0.04 by titania nanoparticles. The contrast of glands is enhanced by titania from 0.68 {+-} 0.12 to 0.84 {+-} 0.07. The highest contrast is reached 120 - 150 min after applying gold nanoshells and 160 - 200 min after applying titania. According to the MC simulation results, the contrast of inclusions increases from zero to 0.85 and 0.65, respectively. (optical tomography)},
doi = {10.1070/QE2010V040N06ABEH014294},
url = {https://www.osti.gov/biblio/21471340}, journal = {Quantum Electronics (Woodbury, N.Y.)},
issn = {1063-7818},
number = 6,
volume = 40,
place = {United States},
year = {Fri Aug 27 00:00:00 EDT 2010},
month = {Fri Aug 27 00:00:00 EDT 2010}
}