Head and neck cancer due to heavy metal exposure via tobacco smoking and professional exposure: A review

Journal Article · Fri Oct 15 00:00:00 EDT 2010 · Toxicology and Applied Pharmacology

DOI:https://doi.org/10.1016/j.taap.2010.08.003· OSTI ID:21451187

Khlifi, Rim; Hamza-Chaffai, Amel

Chronic exposures to heavy metals via tobacco smoking and professional exposure may increase the risk of head and neck cancer, although the epidemiologic evidence is limited by problems of low study power and inadequate adjustment for tobacco and professional exposure use. Numerous scientific reviews have examined the association of various heavy metals exposure with respiratory cancer as well as other cancer types, but few have been published on head and neck cancer. The purpose of this paper, therefore, is to review the head and neck tract cancer-related data on exposure to heavy metals via smoking and working exposure and to study the major mechanisms underlying some toxic metals carcinogenesis.

• OSTI ID: 21451187
• Journal Information: Toxicology and Applied Pharmacology, Vol. 248, Issue 2; Other Information: DOI: 10.1016/j.taap.2010.08.003; PII: S0041-008X(10)00276-0; Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; ISSN 0041-008X
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS
CARCINOGENESIS
CHRONIC EXPOSURE
HEAD
HEALTH HAZARDS
HEAVY METALS
NECK
NEOPLASMS
TOBACCO
BODY
DISEASES
ELEMENTS
HAZARDS
METALS
PATHOGENESIS