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Title: Modified COMS Plaques for {sup 125}I and {sup 103}Pd Iris Melanoma Brachytherapy

Abstract

Purpose: Novel plaques are used to treat iris melanoma at the Mayo Clinic Rochester. The plaques are a modification of the Collaborative Ocular Melanoma Study (COMS) 22 mm plaque design with a gold alloy backing, outer lip, and silicone polymer insert. An inner lip surrounds a 10 mm diameter cutout region at the plaque center. Plaques span 360{sup o}, 270{sup o}, and 180{sup o} arcs. This article describes dosimetry for these plaques and others used in the treatment of anterior eye melanomas. Methods and Materials: The EGSnrc user-code BrachyDose is used to perform Monte Carlo simulations. Plaques and seeds are fully modeled. Three-dimensional dose distributions for different plaque models, TG-43 calculations, and {sup 125}I (model 6711) and {sup 103}Pd (model 200) seeds are compared via depth-dose curves, tabulation of doses at points of interest, and isodose contours. Results: Doses at points of interest differ by up to 70% from TG-43 calculations. The inner lip reduces corneal doses. Matching plaque arc length to tumor extent reduces doses to eye regions outside the treatment area. Maintaining the same prescription dose, {sup 103}Pd offers lower doses to critical structures than {sup 125}I, with the exception of the sclera adjacent to the plaque. Conclusion:more » The Mayo Clinic plaques offer several advantages for anterior eye tumor treatments. Doses to regions outside the treatment area are significantly reduced. Doses differ considerably from TG-43 predictions, illustrating the importance of complete Monte Carlo simulations. Calculations take a few minutes on a single CPU, making BrachyDose sufficiently fast for routine clinical treatment planning.« less

Authors:
; ;  [1];  [2]
  1. Mayo Clinic College of Medicine, Rochester, MN (United States)
  2. Ottawa Carleton Institute of Physics, Carleton University, Ottawa, ON (Canada)
Publication Date:
OSTI Identifier:
21451166
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 78; Journal Issue: 4; Other Information: DOI: 10.1016/j.ijrobp.2009.12.002; PII: S0360-3016(09)03606-2; Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRACHYTHERAPY; COMPUTERIZED SIMULATION; DEPTH DOSE DISTRIBUTIONS; EYES; IODINE 125; MELANOMAS; MONTE CARLO METHOD; PALLADIUM 103; PLANNING; RADIATION DOSES; SILICONES; BETA DECAY RADIOISOTOPES; BODY; CALCULATION METHODS; CARCINOMAS; DAYS LIVING RADIOISOTOPES; DISEASES; DOSES; ELECTRON CAPTURE RADIOISOTOPES; EPITHELIOMAS; EVEN-ODD NUCLEI; FACE; HEAD; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IODINE ISOTOPES; ISOTOPES; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC SILICON COMPOUNDS; ORGANS; PALLADIUM ISOTOPES; POLYMERS; RADIATION DOSE DISTRIBUTIONS; RADIOISOTOPES; RADIOLOGY; RADIOTHERAPY; SENSE ORGANS; SILOXANES; SIMULATION; SPATIAL DOSE DISTRIBUTIONS; THERAPY

Citation Formats

Thomson, Rowan M., E-mail: rthomson@physics.carleton.c, Furutani, Keith M, Pulido, Jose S, Stafford, Scott L, and Rogers, D W.O. Modified COMS Plaques for {sup 125}I and {sup 103}Pd Iris Melanoma Brachytherapy. United States: N. p., 2010. Web. doi:10.1016/j.ijrobp.2009.12.002.
Thomson, Rowan M., E-mail: rthomson@physics.carleton.c, Furutani, Keith M, Pulido, Jose S, Stafford, Scott L, & Rogers, D W.O. Modified COMS Plaques for {sup 125}I and {sup 103}Pd Iris Melanoma Brachytherapy. United States. https://doi.org/10.1016/j.ijrobp.2009.12.002
Thomson, Rowan M., E-mail: rthomson@physics.carleton.c, Furutani, Keith M, Pulido, Jose S, Stafford, Scott L, and Rogers, D W.O. 2010. "Modified COMS Plaques for {sup 125}I and {sup 103}Pd Iris Melanoma Brachytherapy". United States. https://doi.org/10.1016/j.ijrobp.2009.12.002.
@article{osti_21451166,
title = {Modified COMS Plaques for {sup 125}I and {sup 103}Pd Iris Melanoma Brachytherapy},
author = {Thomson, Rowan M., E-mail: rthomson@physics.carleton.c and Furutani, Keith M and Pulido, Jose S and Stafford, Scott L and Rogers, D W.O.},
abstractNote = {Purpose: Novel plaques are used to treat iris melanoma at the Mayo Clinic Rochester. The plaques are a modification of the Collaborative Ocular Melanoma Study (COMS) 22 mm plaque design with a gold alloy backing, outer lip, and silicone polymer insert. An inner lip surrounds a 10 mm diameter cutout region at the plaque center. Plaques span 360{sup o}, 270{sup o}, and 180{sup o} arcs. This article describes dosimetry for these plaques and others used in the treatment of anterior eye melanomas. Methods and Materials: The EGSnrc user-code BrachyDose is used to perform Monte Carlo simulations. Plaques and seeds are fully modeled. Three-dimensional dose distributions for different plaque models, TG-43 calculations, and {sup 125}I (model 6711) and {sup 103}Pd (model 200) seeds are compared via depth-dose curves, tabulation of doses at points of interest, and isodose contours. Results: Doses at points of interest differ by up to 70% from TG-43 calculations. The inner lip reduces corneal doses. Matching plaque arc length to tumor extent reduces doses to eye regions outside the treatment area. Maintaining the same prescription dose, {sup 103}Pd offers lower doses to critical structures than {sup 125}I, with the exception of the sclera adjacent to the plaque. Conclusion: The Mayo Clinic plaques offer several advantages for anterior eye tumor treatments. Doses to regions outside the treatment area are significantly reduced. Doses differ considerably from TG-43 predictions, illustrating the importance of complete Monte Carlo simulations. Calculations take a few minutes on a single CPU, making BrachyDose sufficiently fast for routine clinical treatment planning.},
doi = {10.1016/j.ijrobp.2009.12.002},
url = {https://www.osti.gov/biblio/21451166}, journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 4,
volume = 78,
place = {United States},
year = {Mon Nov 15 00:00:00 EST 2010},
month = {Mon Nov 15 00:00:00 EST 2010}
}