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Title: Interobserver Variation of Clinical Target Volume Delineation in Gastric Cancer

Abstract

Purpose: To evaluate interobserver variability in clinical target volume (CTV) delineation in gastric cancer performed with the help of a delineation guide. Patients and Methods: Ten radiotherapy centers that participate in the CRITICS Phase III trial were provided with a delineation atlas, preoperative CT scans, a postoperative planning CT scan, and clinical information for a gastric cancer case and were asked to construct a CTV and create a dosimetric plan according to departmental policy. Results: The volumes of the CTVs and planning target volumes (PTVs) differed greatly, with a mean (SD) CTV volume of 392 (176) cm{sup 3} (range, 240-821cm{sup 3}) and PTV volume of 915 (312) cm{sup 3} (range, 634-1677cm{sup 3}). The overlapping volume was 376cm{sup 3} for the CTV and 890cm{sup 3} for the PTV. The greatest differences in the CTV were seen at the cranial and caudal parts. After planning, dose coverage of the overlapping PTV volume showed less variability than the CTV. Conclusion: In this series of 10 plans, variability of the CTV in postoperative chemoradiotherapy for gastric cancer is large. Strict and clear delineation guidelines should be provided, especially in Phase III multicenter studies. Adaptations of these guidelines should be evaluated in clinical studies.

Authors:
 [1];  [1]; ;  [2];  [1]
  1. Department of Radiotherapy, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands)
  2. Department of Oncology, Karolinska Institute, Stockholm (Sweden)
Publication Date:
OSTI Identifier:
21436088
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 77; Journal Issue: 4; Other Information: DOI: 10.1016/j.ijrobp.2009.06.023; PII: S0360-3016(09)00931-6; Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CAT SCANNING; COMBINED THERAPY; KIDNEYS; NEOPLASMS; RADIOTHERAPY; STOMACH; VARIATIONS; BODY; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DISEASES; GASTROINTESTINAL TRACT; MEDICINE; NUCLEAR MEDICINE; ORGANS; RADIOLOGY; THERAPY; TOMOGRAPHY

Citation Formats

Jansen, Edwin, Nijkamp, Jasper, Gubanski, Michael, Lind, Pehr, and Verheij, Marcel. Interobserver Variation of Clinical Target Volume Delineation in Gastric Cancer. United States: N. p., 2010. Web. doi:10.1016/j.ijrobp.2009.06.023.
Jansen, Edwin, Nijkamp, Jasper, Gubanski, Michael, Lind, Pehr, & Verheij, Marcel. Interobserver Variation of Clinical Target Volume Delineation in Gastric Cancer. United States. https://doi.org/10.1016/j.ijrobp.2009.06.023
Jansen, Edwin, Nijkamp, Jasper, Gubanski, Michael, Lind, Pehr, and Verheij, Marcel. 2010. "Interobserver Variation of Clinical Target Volume Delineation in Gastric Cancer". United States. https://doi.org/10.1016/j.ijrobp.2009.06.023.
@article{osti_21436088,
title = {Interobserver Variation of Clinical Target Volume Delineation in Gastric Cancer},
author = {Jansen, Edwin and Nijkamp, Jasper and Gubanski, Michael and Lind, Pehr and Verheij, Marcel},
abstractNote = {Purpose: To evaluate interobserver variability in clinical target volume (CTV) delineation in gastric cancer performed with the help of a delineation guide. Patients and Methods: Ten radiotherapy centers that participate in the CRITICS Phase III trial were provided with a delineation atlas, preoperative CT scans, a postoperative planning CT scan, and clinical information for a gastric cancer case and were asked to construct a CTV and create a dosimetric plan according to departmental policy. Results: The volumes of the CTVs and planning target volumes (PTVs) differed greatly, with a mean (SD) CTV volume of 392 (176) cm{sup 3} (range, 240-821cm{sup 3}) and PTV volume of 915 (312) cm{sup 3} (range, 634-1677cm{sup 3}). The overlapping volume was 376cm{sup 3} for the CTV and 890cm{sup 3} for the PTV. The greatest differences in the CTV were seen at the cranial and caudal parts. After planning, dose coverage of the overlapping PTV volume showed less variability than the CTV. Conclusion: In this series of 10 plans, variability of the CTV in postoperative chemoradiotherapy for gastric cancer is large. Strict and clear delineation guidelines should be provided, especially in Phase III multicenter studies. Adaptations of these guidelines should be evaluated in clinical studies.},
doi = {10.1016/j.ijrobp.2009.06.023},
url = {https://www.osti.gov/biblio/21436088}, journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 4,
volume = 77,
place = {United States},
year = {Thu Jul 15 00:00:00 EDT 2010},
month = {Thu Jul 15 00:00:00 EDT 2010}
}