One Year Clinical Outcomes of Renal Artery Stenting: The Results of ODORI Registry
- Hopital Europeen Georges Pompidou, Cardiovascular Radiology (France)
- Wolson Hospital Holon, Department of Invasive Cardiology (Israel)
- Universite Catholique de Louvain, Clinique St. Luc, Department of Vascular and Interventional Radiology (Belgium)
- Kent and Canterbury Hospital, Vascular and Interventional Radiology (United Kingdom)
- Centre Cardiologique du Nord, Department of Interventional Radiology (France)
- 'Sapienza' - University of Rome, Department of Radiological Sciences (Italy)
- Klinikum Karlsruhe, Central Institute for Imaging Diagnostic (Germany)
- Centre Hospitalier Regional Universitaire de Lille, Hopital Cardiologique (France)
- Centre Medico-chirurgical et Maternite de Parly 2, Department of Radiology (France)
- University Hospital Gasthuizberg, Department of Radiology (Belgium)
- Republican Clinical Hospital (Russian Federation)
- University Hospital of Heraklion, Medical School of Crete, Department of Radiology (Greece)
- University of Kentucky Medical Center, Division of Vascular and Interventional Radiology (United States)
The safety, efficacy and long term clinical benefits of renal artery revascularization by stenting are still a matter of debate. The aim of our study was to define the safety and efficacy of renal artery stenting with the Tsunami peripheral stent (Terumo Corporation, Tokyo, Japan). The ODORI was a prospective, multicentre registry which enrolled 251 consecutive patients, (276 renal arteries) in 36 centres across Europe. The primary endpoint was acute procedural success defined as <30% residual stenosis after stent placement. Secondary endpoints included major adverse events, blood pressure control, serum creatinine level, and target lesion revascularization (TLR) at 6 and 12 months. Patients were 70 {+-} 10 years old, 59% were male, 33% had diabetes, and 96% hypertension. The main indications for renal stent implantation were hypertension in 83% and renal salvage in 39%. Direct stent implantation was performed in 76% of the cases. Acute success rate was 100% with residual stenosis of 2.5 {+-} 5.4%. Systolic/diastolic blood pressure decreased from a mean of 171/89 at baseline to 142/78 mmHg at 6 months (p < 0.0001 vs. baseline), and 141/80 mmHg at 12 months (p < 0.0001 vs. baseline). Mean serum creatinine concentration did not change significantly in the total population. However, there was significant improvement in the highest tercile (from 283 {mu}mol/l at baseline to 205 and 209 {mu}mol/l at 6 and 12 months respectively). At 12-months, rates of restenosis and TLR were 6.6 and 0.8% respectively. The 12 month cumulative rate of all major clinical adverse events was 6.4% while the rate of device or procedure related events was 2.4%. In hypertensive patients with atherosclerotic renal artery stenosis Tsunami peripheral balloon-expandable stent provides a safe revascularization strategy, with a potential beneficial impact on hypertension control and renal function in the highest risk patients.
- OSTI ID:
- 21428990
- Journal Information:
- Cardiovascular and Interventional Radiology, Vol. 33, Issue 3; Other Information: DOI: 10.1007/s00270-009-9733-1; Copyright (c) 2010 Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); Article Copyright (c) 2009 The Author(s); ISSN 0174-1551
- Country of Publication:
- United States
- Language:
- English
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