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Title: Is 3T-MR Spectroscopy a Predictable Selection Tool in Prophylactic Vertebroplasty?

Abstract

This study was designed to confirm relationships between decrease of bone mineral density and increase of marrow fat and to delineate, through MR spectroscopy, vertebral body at high risk for compression fracture onset to justify prophylactic vertebroplasty. We enrolled 127 women: 48 osteoporotic, 36 osteopenic, and 43 normal subjects, who underwent DXA and MR examination of spine. Then, we selected 48 patients with at least two acute osteoporotic vertebral fractures with interposed normal 'sandwich' vertebrae; all patients underwent MR examination of spine. Significant statistical differences were found among 'Fat Fraction' (FF) values in normal, osteopenic, and osteoporotic subjects: 59.8 {+-} 5.1%; 64.8 {+-} 4.4%; and 67.1 {+-} 3.3%. A mild, significant, negative correlation was observed between T-score and vertebral fat content (r = - 0.585; P = 0.0000). In the second part of the study, 9 new vertebral fractures were observed in 48 patients (19%): 6 were 'sandwich' vertebrae (12.5%), and 3 were located in distant vertebral body. The mean FF in sandwich fractured vertebrae was 72.75 {+-} 1.95 compared with the FF of the nonfractured sandwich, and distant control vertebrae were 61.83 {+-} 3.42 and 61.42 {+-} 3.64. We found a significant statistical difference between fractured and nonfractured vertebraemore » (P < 0.001). The results of this study suggest that MR spectroscopy could be a reliable index to predict the risk of new compression vertebral fracture and could be used for vertebroplasty planning contributing to clarify the possibility to add prophylactic PVP to standard treatment.« less

Authors:
; ; ; ; ; ;  [1]
  1. University Hospital of 'Tor Vergata', Department of Diagnostic and Molecular Imaging, Interventional Radiology and Radiation Therapy (Italy)
Publication Date:
OSTI Identifier:
21428895
Resource Type:
Journal Article
Journal Name:
Cardiovascular and Interventional Radiology
Additional Journal Information:
Journal Volume: 33; Journal Issue: 6; Other Information: DOI: 10.1007/s00270-010-9821-2; Copyright (c) 2010 Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); Journal ID: ISSN 0174-1551
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; COMPRESSION; FRACTURES; MAGNETIC RESONANCE; OSTEOPOROSIS; SPECTROSCOPY; VERTEBRAE; BODY; DISEASES; FAILURES; ORGANS; RESONANCE; SKELETAL DISEASES; SKELETON

Citation Formats

Masala, S, Massari, F, Assako, Ondo P., E-mail: assakoparfait@yahoo.fr, Meschini, A, Mammucari, M, Ludovici, A, Fanucci, E, and Simonetti, G. Is 3T-MR Spectroscopy a Predictable Selection Tool in Prophylactic Vertebroplasty?. United States: N. p., 2010. Web. doi:10.1007/S00270-010-9821-2.
Masala, S, Massari, F, Assako, Ondo P., E-mail: assakoparfait@yahoo.fr, Meschini, A, Mammucari, M, Ludovici, A, Fanucci, E, & Simonetti, G. Is 3T-MR Spectroscopy a Predictable Selection Tool in Prophylactic Vertebroplasty?. United States. https://doi.org/10.1007/S00270-010-9821-2
Masala, S, Massari, F, Assako, Ondo P., E-mail: assakoparfait@yahoo.fr, Meschini, A, Mammucari, M, Ludovici, A, Fanucci, E, and Simonetti, G. 2010. "Is 3T-MR Spectroscopy a Predictable Selection Tool in Prophylactic Vertebroplasty?". United States. https://doi.org/10.1007/S00270-010-9821-2.
@article{osti_21428895,
title = {Is 3T-MR Spectroscopy a Predictable Selection Tool in Prophylactic Vertebroplasty?},
author = {Masala, S and Massari, F and Assako, Ondo P., E-mail: assakoparfait@yahoo.fr and Meschini, A and Mammucari, M and Ludovici, A and Fanucci, E and Simonetti, G},
abstractNote = {This study was designed to confirm relationships between decrease of bone mineral density and increase of marrow fat and to delineate, through MR spectroscopy, vertebral body at high risk for compression fracture onset to justify prophylactic vertebroplasty. We enrolled 127 women: 48 osteoporotic, 36 osteopenic, and 43 normal subjects, who underwent DXA and MR examination of spine. Then, we selected 48 patients with at least two acute osteoporotic vertebral fractures with interposed normal 'sandwich' vertebrae; all patients underwent MR examination of spine. Significant statistical differences were found among 'Fat Fraction' (FF) values in normal, osteopenic, and osteoporotic subjects: 59.8 {+-} 5.1%; 64.8 {+-} 4.4%; and 67.1 {+-} 3.3%. A mild, significant, negative correlation was observed between T-score and vertebral fat content (r = - 0.585; P = 0.0000). In the second part of the study, 9 new vertebral fractures were observed in 48 patients (19%): 6 were 'sandwich' vertebrae (12.5%), and 3 were located in distant vertebral body. The mean FF in sandwich fractured vertebrae was 72.75 {+-} 1.95 compared with the FF of the nonfractured sandwich, and distant control vertebrae were 61.83 {+-} 3.42 and 61.42 {+-} 3.64. We found a significant statistical difference between fractured and nonfractured vertebrae (P < 0.001). The results of this study suggest that MR spectroscopy could be a reliable index to predict the risk of new compression vertebral fracture and could be used for vertebroplasty planning contributing to clarify the possibility to add prophylactic PVP to standard treatment.},
doi = {10.1007/S00270-010-9821-2},
url = {https://www.osti.gov/biblio/21428895}, journal = {Cardiovascular and Interventional Radiology},
issn = {0174-1551},
number = 6,
volume = 33,
place = {United States},
year = {Wed Dec 15 00:00:00 EST 2010},
month = {Wed Dec 15 00:00:00 EST 2010}
}