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Title: Endovascular Thrombolysis Using Monteplase for Non-chronic Deep Venous Thrombosis

Abstract

This study was designed to evaluate the usefulness of endovascular thrombolysis using monteplase for deep venous thrombosis (DVT). Between December 2005 and October 2009, at our institution nine endovascular thrombolysis treatments with monteplase were performed for symptomatic DVT in eight patients (6 women, 2 men; mean age, 56 (range, 15-80) years). In all, systemic anticoagulation administered by the peripheral intravenous route with heparin and/or thrombolysis with urokinase followed by anticoagulation with orally administered warfarin had been performed, and subsequently six endovascular treatments without monteplase were administered. However, DVT persisted, and endovascular treatments with monteplase were tried. In six (67%) of the nine procedures, DVT completely or almost completely disappeared after endovascular thrombolysis with monteplase. Mean dose of monteplase used was 2,170,000 IU. There was only one procedure-related complication. In one patient, just after thrombolysis with monteplase, bleeding at the puncture site and gingival bleeding occurred. Bleeding was stopped by manual astriction only. Endovascular thrombolysis with monteplase may be an effective treatment for DVT, even in cases resistant to traditional systemic anticoagulation and thrombolysis and endovascular procedures without monteplase.

Authors:
; ; ; ;  [1]
  1. Kyoto Prefectural University of Medicine, Department of Radiology, Graduate School of Medical Science (Japan)
Publication Date:
OSTI Identifier:
21428889
Resource Type:
Journal Article
Journal Name:
Cardiovascular and Interventional Radiology
Additional Journal Information:
Journal Volume: 33; Journal Issue: 6; Other Information: DOI: 10.1007/s00270-010-9856-4; Copyright (c) 2010 Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); Journal ID: ISSN 0174-1551
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; HEPARIN; THROMBOSIS; UROKINASE; VEINS; AMINES; ANTICOAGULANTS; BLOOD COAGULATION FACTORS; BLOOD VESSELS; BODY; CARBOHYDRATES; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; DISEASES; DRUGS; ENZYMES; FIBRINOLYTIC AGENTS; HEMATOLOGIC AGENTS; HYDROLASES; MUCOPOLYSACCHARIDES; NONSPECIFIC PEPTIDASES; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; PEPTIDE HYDROLASES; POLYSACCHARIDES; PROTEINS; SACCHARIDES; VASCULAR DISEASES

Citation Formats

Yamagami, Takuji, Yoshimatsu, Rika, Tanaka, Osamu, Miura, Hiroshi, and Nishimura, Tsunehiko. Endovascular Thrombolysis Using Monteplase for Non-chronic Deep Venous Thrombosis. United States: N. p., 2010. Web. doi:10.1007/S00270-010-9856-4.
Yamagami, Takuji, Yoshimatsu, Rika, Tanaka, Osamu, Miura, Hiroshi, & Nishimura, Tsunehiko. Endovascular Thrombolysis Using Monteplase for Non-chronic Deep Venous Thrombosis. United States. https://doi.org/10.1007/S00270-010-9856-4
Yamagami, Takuji, Yoshimatsu, Rika, Tanaka, Osamu, Miura, Hiroshi, and Nishimura, Tsunehiko. 2010. "Endovascular Thrombolysis Using Monteplase for Non-chronic Deep Venous Thrombosis". United States. https://doi.org/10.1007/S00270-010-9856-4.
@article{osti_21428889,
title = {Endovascular Thrombolysis Using Monteplase for Non-chronic Deep Venous Thrombosis},
author = {Yamagami, Takuji and Yoshimatsu, Rika and Tanaka, Osamu and Miura, Hiroshi and Nishimura, Tsunehiko},
abstractNote = {This study was designed to evaluate the usefulness of endovascular thrombolysis using monteplase for deep venous thrombosis (DVT). Between December 2005 and October 2009, at our institution nine endovascular thrombolysis treatments with monteplase were performed for symptomatic DVT in eight patients (6 women, 2 men; mean age, 56 (range, 15-80) years). In all, systemic anticoagulation administered by the peripheral intravenous route with heparin and/or thrombolysis with urokinase followed by anticoagulation with orally administered warfarin had been performed, and subsequently six endovascular treatments without monteplase were administered. However, DVT persisted, and endovascular treatments with monteplase were tried. In six (67%) of the nine procedures, DVT completely or almost completely disappeared after endovascular thrombolysis with monteplase. Mean dose of monteplase used was 2,170,000 IU. There was only one procedure-related complication. In one patient, just after thrombolysis with monteplase, bleeding at the puncture site and gingival bleeding occurred. Bleeding was stopped by manual astriction only. Endovascular thrombolysis with monteplase may be an effective treatment for DVT, even in cases resistant to traditional systemic anticoagulation and thrombolysis and endovascular procedures without monteplase.},
doi = {10.1007/S00270-010-9856-4},
url = {https://www.osti.gov/biblio/21428889}, journal = {Cardiovascular and Interventional Radiology},
issn = {0174-1551},
number = 6,
volume = 33,
place = {United States},
year = {Wed Dec 15 00:00:00 EST 2010},
month = {Wed Dec 15 00:00:00 EST 2010}
}