CT-Guided Radiofrequency Ablation in Patients with Hepatic Metastases from Breast Cancer
- Ludwig-Maximilians-University of Munich, Department of Radiology (Germany)
- Ludwig-Maximilians-University of Munich, Department of Internal Medicine III (Germany)
- University of Schleswig-Holstein, Department of Radiology (Germany)
- The University of Texas M. D. Anderson Cancer Center, Division of Diagnostic Imaging (United States)
- Klinikum Bogenhausen, Department of Radiology (Germany)
The purpose of this study was to evaluate technical success, technique effectiveness, and survival following radiofrequency ablation for breast cancer liver metastases and to determine prognostic factors. Forty-three patients with 111 breast cancer liver metastases underwent CT-guided percutaneous radiofrequency (RF) ablation. Technical success and technique effectiveness was evaluated by performing serial CT scans. We assessed the prognostic value of hormone receptor status, overexpression of human epidermal growth factor receptor 2 (HER2), and presence of extrahepatic tumor spread. Survival rates were calculated using the Kaplan-Meier method. Technical success was achieved in 107 metastases (96%). Primary technique effectiveness was 96%. During follow-up local tumor progression was observed in 15 metastases, representing a secondary technique effectiveness of 86.5%. The overall time to progression to the liver was 10.5 months. The estimated overall median survival was 58.6 months. There was no significant difference in terms of survival probability with respect to hormone receptor status, HER2 overexpression, and presence of isolated bone metastases. Survival was significantly lower among patients with extrahepatic disease, with the exception of skeletal metastases. We conclude that CT-guided RF ablation of liver metastases from breast cancer can be performed with a high degree of technical success and technique effectiveness, providing promising survival rates in patients with no visceral extrahepatic disease. Solitary bone metastases did not negatively affect survival probability after RF ablation.
- OSTI ID:
- 21426327
- Journal Information:
- Cardiovascular and Interventional Radiology, Vol. 32, Issue 1; Conference: BSIR 2008: Annual meeting of the Cardiovascular and Interventional Radiology Society of Europe, Manchester (United Kingdom), 5-7 Nov 2008; Other Information: DOI: 10.1007/s00270-008-9384-7; Copyright (c) 2009 Springer Science+Business Media, LLC; ISSN 0174-1551
- Country of Publication:
- United States
- Language:
- English
Similar Records
Is Ki-67 Expression Prognostic for Local Relapse in Early-Stage Breast Cancer Patients Treated With Breast Conservation Therapy (BCT)?
Triple-Negative or HER2-Positive Status Predicts Higher Rates of Locoregional Recurrence in Node-Positive Breast Cancer Patients After Mastectomy