Creation of a Tumor-Mimic Model Using a Muscle Paste for Radiofrequency Ablation of the Lung

Journal Article · Sun Mar 15 00:00:00 EDT 2009 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-008-9463-9· OSTI ID:21426304

Kawai, T; Kaminou, T; Sugiura, K; Hashimoto, M; Ohuchi, Y; Adachi, A ^[1]; Fujioka, S; Ito, H ^[2]; Nakamura, K ^[3]; Ogawa, T ^[1]

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1. Tottori University, Division of Radiology, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine (Japan)
2. Tottori University, Division of Organ Pathology, Department of Microbiology and Pathology, Faculty of Medicine (Japan)
3. Hakuai Hospital, Department of Radiology (Japan)

The purpose of this study was to develop an easily created tumor-mimic model and evaluate its efficacy for radiofrequency ablation (RFA) of the lung. The bilateral lungs of eight living adult swine were used. A tumor-mimic model was made by percutaneous injection of 1.0 ml muscle paste through the bone biopsy needle into the lung. An RFA probe was then inserted into the tumor mimics immediately after tumor creation. Ablation time, tissue impedance, and temperature were recorded. The tumor mimics and their coagulated regions were evaluated microscopically and macroscopically. The muscle paste was easily injected into the lung parenchyma through the bone biopsy needle and well visualized under fluoroscopy. In 10 of 12 sites the tumor mimics were oval shaped, localized, and homogeneous on gross specimens. Ten tumor mimics were successfully ablated, and four locations were ablated in the normal lung parenchyma as controls. In the tumor and normal lung parenchyma, ablation times were 8.9 {+-} 3.5 and 4.4 {+-} 1.6 min, respectively; tissue impedances at the start of ablation were 100.6 {+-} 16.6 and 145.8 {+-} 26.8 {Omega}, respectively; and temperatures at the end of ablation were 66.0 {+-} 7.9 and 57.5 {+-} 7.6{sup o}C, respectively. The mean size of tumor mimics was 13.9 x 8.2 mm, and their coagulated area was 18.8 x 13.1 mm. In the lung parenchyma, the coagulated area was 15.3 x 12.0 mm. In conclusion, our tumor-mimic model using muscle paste can be easily and safely created and can be ablated using the ablation algorithm in the clinical setting.

• OSTI ID: 21426304
• Journal Information: Cardiovascular and Interventional Radiology, Vol. 32, Issue 2; Other Information: DOI: 10.1007/s00270-008-9463-9; Copyright (c) 2009 Springer Science+Business Media, LLC; ISSN 0174-1551
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ABLATION
FLUOROSCOPY
LUNGS
MUSCLES
NEOPLASMS
RADIOWAVE RADIATION
SWINE
ANIMALS
BIOMEDICAL RADIOGRAPHY
BODY
DIAGNOSTIC TECHNIQUES
DISEASES
DOMESTIC ANIMALS
ELECTROMAGNETIC RADIATION
MAMMALS
MEDICINE
NUCLEAR MEDICINE
ORGANS
RADIATIONS
RADIOLOGY
RESPIRATORY SYSTEM
VERTEBRATES