Boron Neutron Capture Therapy (BNCT) Dose Calculation using Geometrical Factors Spherical Interface for Glioblastoma Multiforme

Journal Article · Tue Jun 22 00:00:00 EDT 2010 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.3462755· OSTI ID:21415258

Zasneda, Sabriani; Widita, Rena ^[1]

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1. Department of Physics, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jl. Ganesha No. 10 Bandung, 40132 (Indonesia)

Boron Neutron Capture Therapy (BNCT) is a cancer therapy by utilizing thermal neutron to produce alpha particles and lithium nuclei. The superiority of BNCT is that the radiation effects could be limited only for the tumor cells. BNCT radiation dose depends on the distribution of boron in the tumor. Absorbed dose to the cells from the reaction 10B (n, {alpha}) 7Li was calculated near interface medium containing boron and boron-free region. The method considers the contribution of the alpha particle and recoiled lithium particle to the absorbed dose and the variation of Linear Energy Transfer (LET) charged particles energy. Geometrical factor data of boron distribution for the spherical surface is used to calculate the energy absorbed in the tumor cells, brain and scalp for case Glioblastoma Multiforme. The result shows that the optimal dose in tumor is obtained for boron concentrations of 22.1 mg {sup 10}B/g blood.

• OSTI ID: 21415258
• Journal Information: AIP Conference Proceedings, Vol. 1244, Issue 1; Conference: ICANSE 2009: 2. international conference on advances in nuclear science and engineering 2009, Bandung (Indonesia), 3-4 Nov 2009; Other Information: DOI: 10.1063/1.3462755; (c) 2010 American Institute of Physics; ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ALPHA DECAY
ALPHA PARTICLES
BLOOD
BORON 10 TARGET
BRAIN
DISTRIBUTION
ENERGY STORAGE
GLIOMAS
INTERFACES
LET
LITHIUM 7
NEOPLASMS
NEUTRON CAPTURE THERAPY
NEUTRON REACTIONS
RADIATION DOSES
SPHERICAL CONFIGURATION
SURFACES
THERMAL NEUTRONS
TUMOR CELLS
ANIMAL CELLS
BARYON REACTIONS
BARYONS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CENTRAL NERVOUS SYSTEM
CHARGED PARTICLES
CONFIGURATION
DECAY
DISEASES
DOSES
ELEMENTARY PARTICLES
ENERGY TRANSFER
FERMIONS
HADRON REACTIONS
HADRONS
IONIZING RADIATIONS
ISOTOPES
LIGHT NUCLEI
LITHIUM ISOTOPES
MATERIALS
MEDICINE
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NEUTRON THERAPY
NEUTRONS
NUCLEAR DECAY
NUCLEAR MEDICINE
NUCLEAR REACTIONS
NUCLEI
NUCLEON REACTIONS
NUCLEONS
ODD-EVEN NUCLEI
ORGANS
RADIATIONS
RADIOLOGY
RADIOTHERAPY
STABLE ISOTOPES
STORAGE
TARGETS
THERAPY