3D dose and TCP distribution for radionuclide therapy in nuclear medicine

Journal Article · Wed Aug 04 00:00:00 EDT 2010 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.3480223· OSTI ID:21410827

Valente, M; Malano, F ^[1]; Perez, P ^[1]

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1. FaMAF, Universidad Nacional de Cordoba, Argentina. Medina Allende y Haya de la Torre, C. Universitaria, Cordoba (X5000HUA) (Argentina)

A common feature to any radiant therapy is that lesion and health tissue dosimetry provides relevant information for treatment optimization along with dose-efficacy and dose-complication correlation studies. Nowadays, different radionuclide therapies are commonly available, assessing both systemic and loco-regional approach and using different alfa-, beta-and gamma-emitting isotopes and binding molecules. It is well established, that specific dosimetric approaches become necessary according to each therapy modality. Sometimes, observed activity distribution can be satisfactory represented by simple geometrical models. However, Monte Carlo techniques are capable of better approaches, therefore becoming sometimes the only way to get dosimetric data since the patient-specific situation can not be adequately represented by conventional dosimetry techniques. Therefore, due to strong limitations of traditional and standard methods, this work concentrates on the development of a dedicated and novel calculation system in order to assess the dose distribution within the irradiated patient. However, physical dose may not be enough information in order to establish real deterministic biological/metabolic effects; therefore complementary radiobiological models have been suitably introduced with the aim of performing realistic 3D dose as well as corresponding Tumor Control Probability distribution calculation.

• OSTI ID: 21410827
• Journal Information: AIP Conference Proceedings, Vol. 1265, Issue 1; Conference: 8. Latin American symposium on nuclear physics and applications, Santiago (Chile), 15-19 Dec 2009; Other Information: DOI: 10.1063/1.3480223; (c) 2010 American Institute of Physics; ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BIOLOGICAL RADIATION EFFECTS
CORRELATIONS
DISTRIBUTION
DOSIMETRY
MONTE CARLO METHOD
NEOPLASMS
PATIENTS
RADIATION DOSE DISTRIBUTIONS
RADIATION DOSES
RADIATION PROTECTION
RADIOISOTOPES
RADIOTHERAPY
TCP
BIOLOGICAL EFFECTS
CALCULATION METHODS
DISEASES
DOSES
ESTERS
ISOTOPES
MEDICINE
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PHOSPHORIC ACID ESTERS
RADIATION EFFECTS
RADIOLOGY
THERAPY