Radiation Dose-Volume Effects in the Heart
Journal Article
·
· International Journal of Radiation Oncology, Biology and Physics
- Department of Medical Physics, Karolinska University Hospital and Karolinska Institute, Stockholm (Sweden)
- Department of Radiation Oncology, University of Rochester Cancer Center, Rochester, NY (United States)
- Vancouver Cancer Centre, British Columbia Cancer Agency, Vancouver, BC (Canada)
- Department of Radiation Oncology, University of Michigan, Ann Arbor, MI (United States)
- Department of Radiation Oncology, Dana- Farber Cancer Institute, Boston, MA (United States)
- Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC (United States)
The literature is reviewed to identify the main clinical and dose-volume predictors for acute and late radiation-induced heart disease. A clear quantitative dose and/or volume dependence for most cardiac toxicity has not yet been shown, primarily because of the scarcity of the data. Several clinical factors, such as age, comorbidities and doxorubicin use, appear to increase the risk of injury. The existing dose-volume data is presented, as well as suggestions for future investigations to better define radiation-induced cardiac injury.
- OSTI ID:
- 21372134
- Journal Information:
- International Journal of Radiation Oncology, Biology and Physics, Vol. 76, Issue 3; Other Information: DOI: 10.1016/j.ijrobp.2009.04.093; PII: S0360-3016(09)03290-8; Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; ISSN 0360-3016
- Country of Publication:
- United States
- Language:
- English
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