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Title: Fertility and Pregnancy Outcome After Abdominal Irradiation That Included or Excluded the Pelvis in Childhood Tumor Survivors

Abstract

Purpose: To evaluate fertility after abdominal and/or pelvic irradiation in long-term female survivors. Methods and Materials: Puberty and pregnancy outcome were analyzed in female survivors of childhood cancer (aged <18 years) treated with abdominal and/or pelvic radiotherapy (RT) at one of two French centers (Nancy and Lyon) between 1975 and 2004. Data were obtained from medical records and questionnaires sent to the women. Results: A total of 84 patients who had received abdominal and/or pelvic RT during childhood and were alive and aged more than 18 years at the time of the study made up the study population. Of the 57 female survivors treated with abdominal RT that excluded the pelvis, 52 (91%) progressed normally through puberty and 23 (40%) had at least one recorded pregnancy. Of the 27 patients treated with pelvic RT, only 10 (37%) progressed normally through puberty and 5 (19%) had at least one recorded pregnancy. Twenty-two women (seventeen of whom were treated with pelvic RT) had certain subfertility. A total of 50 births occurred in 28 women, with one baby dying at birth; one miscarriage also occurred. There was a high prevalence of prematurity and low birth weight but not of congenital malformations. Conclusions: Fertilitymore » can be preserved in patients who undergo abdominal RT that excludes the pelvis, taking into account the other treatments (e.g., chemotherapy with alkylating agents) are taken into account. When RT includes the pelvis, fertility is frequently impaired and women can have difficulty conceiving. Nevertheless, pregnancies can occur in some of these women. The most important factor that endangers a successful pregnancy after RT is the total dose received by the ovaries and uterus. This radiation dose has to be systematically recorded to improve our ability to follow up patients.« less

Authors:
 [1];  [1];  [2];  [3];  [4];  [2];  [5]
  1. Department of Paediatric Onco-Hematology, CHU Nancy, Vandoeuvre-les-Nancy (France)
  2. Department of Radiotherapy, Centre Leon Berard, Lyon (France)
  3. Department of Statistics, Centre Alexis Vautrin, Vandoeuvre-les-Nancy (France)
  4. Department of Endocrinology, CHU Nancy, Vandoeuvre-les-Nancy (France)
  5. Department of Radiotherapy, Centre Alexis Vautrin, Vandoeuvre-les-Nancy (France)
Publication Date:
OSTI Identifier:
21372113
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 76; Journal Issue: 3; Other Information: DOI: 10.1016/j.ijrobp.2009.04.012; PII: S0360-3016(09)00568-9; Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ABDOMEN; FERTILITY; NEOPLASMS; OVARIES; PELVIS; PREGNANCY; RADIATION DOSES; RADIOTHERAPY; UTERUS; WOMEN; ANIMALS; BODY; DISEASES; DOSES; FEMALE GENITALS; FEMALES; GONADS; MAMMALS; MAN; MEDICINE; NUCLEAR MEDICINE; ORGANS; PRIMATES; RADIOLOGY; THERAPY; VERTEBRATES

Citation Formats

Sudour, Helene, Chastagner, Pascal, Claude, Line, Desandes, Emmanuel, Klein, Marc, Carrie, Christian, and Bernier, Valerie. Fertility and Pregnancy Outcome After Abdominal Irradiation That Included or Excluded the Pelvis in Childhood Tumor Survivors. United States: N. p., 2010. Web. doi:10.1016/j.ijrobp.2009.04.012.
Sudour, Helene, Chastagner, Pascal, Claude, Line, Desandes, Emmanuel, Klein, Marc, Carrie, Christian, & Bernier, Valerie. Fertility and Pregnancy Outcome After Abdominal Irradiation That Included or Excluded the Pelvis in Childhood Tumor Survivors. United States. https://doi.org/10.1016/j.ijrobp.2009.04.012
Sudour, Helene, Chastagner, Pascal, Claude, Line, Desandes, Emmanuel, Klein, Marc, Carrie, Christian, and Bernier, Valerie. 2010. "Fertility and Pregnancy Outcome After Abdominal Irradiation That Included or Excluded the Pelvis in Childhood Tumor Survivors". United States. https://doi.org/10.1016/j.ijrobp.2009.04.012.
@article{osti_21372113,
title = {Fertility and Pregnancy Outcome After Abdominal Irradiation That Included or Excluded the Pelvis in Childhood Tumor Survivors},
author = {Sudour, Helene and Chastagner, Pascal and Claude, Line and Desandes, Emmanuel and Klein, Marc and Carrie, Christian and Bernier, Valerie},
abstractNote = {Purpose: To evaluate fertility after abdominal and/or pelvic irradiation in long-term female survivors. Methods and Materials: Puberty and pregnancy outcome were analyzed in female survivors of childhood cancer (aged <18 years) treated with abdominal and/or pelvic radiotherapy (RT) at one of two French centers (Nancy and Lyon) between 1975 and 2004. Data were obtained from medical records and questionnaires sent to the women. Results: A total of 84 patients who had received abdominal and/or pelvic RT during childhood and were alive and aged more than 18 years at the time of the study made up the study population. Of the 57 female survivors treated with abdominal RT that excluded the pelvis, 52 (91%) progressed normally through puberty and 23 (40%) had at least one recorded pregnancy. Of the 27 patients treated with pelvic RT, only 10 (37%) progressed normally through puberty and 5 (19%) had at least one recorded pregnancy. Twenty-two women (seventeen of whom were treated with pelvic RT) had certain subfertility. A total of 50 births occurred in 28 women, with one baby dying at birth; one miscarriage also occurred. There was a high prevalence of prematurity and low birth weight but not of congenital malformations. Conclusions: Fertility can be preserved in patients who undergo abdominal RT that excludes the pelvis, taking into account the other treatments (e.g., chemotherapy with alkylating agents) are taken into account. When RT includes the pelvis, fertility is frequently impaired and women can have difficulty conceiving. Nevertheless, pregnancies can occur in some of these women. The most important factor that endangers a successful pregnancy after RT is the total dose received by the ovaries and uterus. This radiation dose has to be systematically recorded to improve our ability to follow up patients.},
doi = {10.1016/j.ijrobp.2009.04.012},
url = {https://www.osti.gov/biblio/21372113}, journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 3,
volume = 76,
place = {United States},
year = {Mon Mar 01 00:00:00 EST 2010},
month = {Mon Mar 01 00:00:00 EST 2010}
}