Quantifying Local Radiation-Induced Lung Damage From Computed Tomography
- Department of Radiation Oncology, University Medical Center Groningen/University of Groningen, Groningen (Netherlands)
- Department of Radiology, University Medical Center Groningen/University of Groningen, Groningen (Netherlands)
- Kernfysisch Versneller Instituut, Groningen (Netherlands)
Purpose: Optimal implementation of new radiotherapy techniques requires accurate predictive models for normal tissue complications. Since clinically used dose distributions are nonuniform, local tissue damage needs to be measured and related to local tissue dose. In lung, radiation-induced damage results in density changes that have been measured by computed tomography (CT) imaging noninvasively, but not yet on a localized scale. Therefore, the aim of the present study was to develop a method for quantification of local radiation-induced lung tissue damage using CT. Methods and Materials: CT images of the thorax were made 8 and 26 weeks after irradiation of 100%, 75%, 50%, and 25% lung volume of rats. Local lung tissue structure (S{sub L}) was quantified from local mean and local standard deviation of the CT density in Hounsfield units in 1-mm{sup 3} subvolumes. The relation of changes in S{sub L} (DELTAS{sub L}) to histologic changes and breathing rate was investigated. Feasibility for clinical application was tested by applying the method to CT images of a patient with non-small-cell lung carcinoma and investigating the local dose-effect relationship of DELTAS{sub L}. Results: In rats, a clear dose-response relationship of DELTAS{sub L} was observed at different time points after radiation. Furthermore, DELTAS{sub L} correlated strongly to histologic endpoints (infiltrates and inflammatory cells) and breathing rate. In the patient, progressive local dose-dependent increases in DELTAS{sub L} were observed. Conclusion: We developed a method to quantify local radiation-induced tissue damage in the lung using CT. This method can be used in the development of more accurate predictive models for normal tissue complications.
- OSTI ID:
- 21372073
- Journal Information:
- International Journal of Radiation Oncology, Biology and Physics, Vol. 76, Issue 2; Other Information: DOI: 10.1016/j.ijrobp.2009.08.058; PII: S0360-3016(09)03038-7; Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; ISSN 0360-3016
- Country of Publication:
- United States
- Language:
- English
Similar Records
WE-AB-207B-05: Correlation of Normal Lung Density Changes with Dose After Stereotactic Body Radiotherapy (SBRT) for Early Stage Lung Cancer
Reconstruction of 3D lung models from 2D planning data sets for Hodgkin's lymphoma patients using combined deformable image registration and navigator channels
Related Subjects
CAT SCANNING
CHEST
LUNGS
RADIATION INJURIES
RADIOTHERAPY
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
INJURIES
MEDICINE
NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIOLOGY
RESPIRATORY SYSTEM
THERAPY
TOMOGRAPHY