Stereotactic Body Radiation Therapy Boost in Locally Advanced Pancreatic Cancer
- Department of Radiation Oncology, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of)
- CyberKnife Center, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of)
- Department of Internal Medicine, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of)
- Department of Pathology, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of)
- Department of Hemato-Oncology, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of)
- Department of Radiology, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of)
Purpose: To investigate the clinical application of a stereotactic body radiation therapy (SBRT) boost in locally advanced pancreatic cancer patients with a focus on local efficacy and toxicity. Methods and Materials: We retrospectively reviewed 30 patients with locally advanced and nonmetastatic pancreatic cancer who had been treated between 2004 and 2006. Follow-up duration ranged from 4 to 41 months (median, 14.5 months). A total dose of 40 Gy was delivered in 20 fractions using a conventional three-field technique, and then a single fraction of 14, 15, 16, or 17 Gy SBRT was administered as a boost without a break. Twenty-one patients received chemotherapy. Overall and local progression-free survival were calculated and prognostic factors were evaluated. Results: One-year overall survival and local progression-free survival rates were 60.0% and 70.2%, respectively. One patient (3%) developed Grade 4 toxicity. Carbohydrate antigen 19-9 response was found to be an independent prognostic factor for survival. Conclusions: Our findings indicate that a SBRT boost provides a safe means of increasing radiation dose. Based on the results of this study, we recommend that a well controlled Phase II study be conducted on locally advanced pancreatic cancer.
- OSTI ID:
- 21367556
- Journal Information:
- International Journal of Radiation Oncology, Biology and Physics, Vol. 75, Issue 5; Other Information: DOI: 10.1016/j.ijrobp.2009.01.042; PII: S0360-3016(09)00138-2; Copyright (c) 2009 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; ISSN 0360-3016
- Country of Publication:
- United States
- Language:
- English
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