Evaluation of gamma-Induced Apoptosis in Human Peripheral Blood Lymphocytes

Journal Article · Tue Jan 05 00:00:00 EST 2010 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.3295662· OSTI ID:21366918

Baranova, Elena ^[1]; Boreyko, Alla; Ravnachka, Ivanka ^[2]; Saveleva, Maria ^[1]

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1. Biophysics Department, Dubna International University of Nature, Society, and Man, 19 Universitetskaya str., 141980 Dubna, Moscow region (Russian Federation)
2. Laboratory for Radiation Biology, JINR, 6 Joliot-Curie str., 141980 Dubna, Moscow region (Russian Federation)

Several experiments have been performed to study regularities in the induction of apoptotic cells in human lymphocytes by {sup 60}Cogamma-rays at different times after irradiation. Apoptosis induction by {sup 60}Cogamma-rays in human lymphocytes in different cell cycle phases (G{sub 0}, S, G{sub 1}, and G{sub 2}) has been studied. The maximal apoptosis output in lymphocyte cells was observed in the S phase. Modifying effect of replicative and reparative DNA synthesis inhibitors - 1-beta-D-arabinofuranosylcytosine (Ara-C) and hydroxyurea (Hu) - on the kinetics of {sup 60}Cogamma-rays induced apoptosis in human lymphocytes has been studied.

• OSTI ID: 21366918
• Journal Information: AIP Conference Proceedings, Vol. 1204, Issue 1; Conference: 5. international summer school on nuclear physics methods and accelerators in biology and medicine, Bratislava (Slovakia), 6-15 Jul 2009; Other Information: DOI: 10.1063/1.3295662; (c) 2009 American Institute of Physics; ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS
APOPTOSIS
CELL CYCLE
DNA
FLUORESCENCE SPECTROSCOPY
GAMMA RADIATION
HUMAN POPULATIONS
HYDROXYUREA
IRRADIATION
LYMPHOCYTES
AMIDES
ANIMAL CELLS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
EMISSION SPECTROSCOPY
HYDROXY COMPOUNDS
IONIZING RADIATIONS
LEUKOCYTES
MATERIALS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
POPULATIONS
RADIATIONS
SOMATIC CELLS
SPECTROSCOPY