Effect of Interval to Definitive Breast Surgery on Clinical Presentation and Survival in Early-Stage Invasive Breast Cancer
Abstract
Purpose: To examine the effect of clinical presentation and interval to breast surgery on local recurrence and survival in early-stage breast cancer. Methods and Materials: The data from 397 patients with Stage T1-T2N0 breast carcinoma treated with conservative surgery and breast radiotherapy between 1985 and 1992 were reviewed at the London Regional Cancer Program. The clinical presentation consisted of a mammogram finding or a palpable lump. The intervals from clinical presentation to definitive breast surgery used for analysis were 0-4, >4-12, and >12 weeks. The Kaplan-Meier estimates of the time to local recurrence, disease-free survival, and cause-specific survival were determined for the three groups. Cox regression analysis was used to evaluate the effect of clinical presentation and interval to definitive surgery on survival. Results: The median follow-up was 11.2 years. No statistically significant difference was found in local recurrence as a function of the interval to definitive surgery (p = .424). A significant difference was noted in disease-free survival (p = .040) and cause-specific survival (p = .006) with an interval of >12 weeks to definitive breast surgery. However, the interval to definitive surgery was dependent on the presentation for cause-specific survival, with a substantial effect for patients with amore »
- Authors:
-
- Department of Radiation Oncology, London Regional Cancer Program, London, ON (Canada)
- Department of Medical Oncology, London Regional Cancer Program, London, ON (Canada)
- Department of Biometry, London Regional Cancer Program, London, ON (Canada)
- Publication Date:
- OSTI Identifier:
- 21362213
- Resource Type:
- Journal Article
- Journal Name:
- International Journal of Radiation Oncology, Biology and Physics
- Additional Journal Information:
- Journal Volume: 75; Journal Issue: 3; Other Information: DOI: 10.1016/j.ijrobp.2008.11.049; PII: S0360-3016(08)03837-6; Copyright (c) 2009 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Journal ID: ISSN 0360-3016
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE; CARCINOMAS; MAMMARY GLANDS; RADIOTHERAPY; REGRESSION ANALYSIS; SURGERY; BODY; DISEASES; GLANDS; MATHEMATICS; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; ORGANS; RADIOLOGY; STATISTICS; THERAPY
Citation Formats
Vujovic, Olga, Yu, Edward, Cherian, Anil, Perera, Francisco, Dar, A Rashid, Stitt, Larry, and Hammond, A. Effect of Interval to Definitive Breast Surgery on Clinical Presentation and Survival in Early-Stage Invasive Breast Cancer. United States: N. p., 2009.
Web. doi:10.1016/j.ijrobp.2008.11.049.
Vujovic, Olga, Yu, Edward, Cherian, Anil, Perera, Francisco, Dar, A Rashid, Stitt, Larry, & Hammond, A. Effect of Interval to Definitive Breast Surgery on Clinical Presentation and Survival in Early-Stage Invasive Breast Cancer. United States. https://doi.org/10.1016/j.ijrobp.2008.11.049
Vujovic, Olga, Yu, Edward, Cherian, Anil, Perera, Francisco, Dar, A Rashid, Stitt, Larry, and Hammond, A. 2009.
"Effect of Interval to Definitive Breast Surgery on Clinical Presentation and Survival in Early-Stage Invasive Breast Cancer". United States. https://doi.org/10.1016/j.ijrobp.2008.11.049.
@article{osti_21362213,
title = {Effect of Interval to Definitive Breast Surgery on Clinical Presentation and Survival in Early-Stage Invasive Breast Cancer},
author = {Vujovic, Olga and Yu, Edward and Cherian, Anil and Perera, Francisco and Dar, A Rashid and Stitt, Larry and Hammond, A},
abstractNote = {Purpose: To examine the effect of clinical presentation and interval to breast surgery on local recurrence and survival in early-stage breast cancer. Methods and Materials: The data from 397 patients with Stage T1-T2N0 breast carcinoma treated with conservative surgery and breast radiotherapy between 1985 and 1992 were reviewed at the London Regional Cancer Program. The clinical presentation consisted of a mammogram finding or a palpable lump. The intervals from clinical presentation to definitive breast surgery used for analysis were 0-4, >4-12, and >12 weeks. The Kaplan-Meier estimates of the time to local recurrence, disease-free survival, and cause-specific survival were determined for the three groups. Cox regression analysis was used to evaluate the effect of clinical presentation and interval to definitive surgery on survival. Results: The median follow-up was 11.2 years. No statistically significant difference was found in local recurrence as a function of the interval to definitive surgery (p = .424). A significant difference was noted in disease-free survival (p = .040) and cause-specific survival (p = .006) with an interval of >12 weeks to definitive breast surgery. However, the interval to definitive surgery was dependent on the presentation for cause-specific survival, with a substantial effect for patients with a mammographic presentation and a negligible effect for patients with a lump presentation (interaction p = .041). Conclusion: The results of this study suggest that an interval of >12 weeks to breast surgery might be associated with decreased survival for patients with a mammographic presentation, but it appeared to have no effect on survival for patients presenting with a palpable breast lump.},
doi = {10.1016/j.ijrobp.2008.11.049},
url = {https://www.osti.gov/biblio/21362213},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 3,
volume = 75,
place = {United States},
year = {Sun Nov 01 00:00:00 EDT 2009},
month = {Sun Nov 01 00:00:00 EDT 2009}
}