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Title: In vivo infection of IgG-containing cells by Jembrana disease virus during acute infection

Abstract

Jembrana disease virus (JDV) is an unusual bovine lentivirus which causes a non-follicular proliferation of lymphocytes, a transient immunosuppression and a delayed humoral response in infected Bali cattle in Indonesia. A double-immunofluorescent labeling method was developed to identify the subset of mononuclear cells in which the viral capsid protein could be detected. Viral antigen was present in pleomorphic centroblast-like cells which were identified as IgG-containing cells, including plasma cells, in lymphoid tissues. There was no evidence of infection of CD3{sup +} T-cells or MAC387{sup +} monocytes in tissues but large vacuolated cells with a macrophage-like morphology in the lung were found to contain viral antigen although they could not be shown conclusively to be infected. The tropism of JDV for mature IgG-containing cells may be relevant to understanding the pathogenesis of Jembrana disease, the delayed antibody responses and the genetic composition of this atypical lentivirus.

Authors:
 [1];  [1]; ; ;  [1];  [2];  [1]
  1. School of Veterinary and Biomedical Science, Murdoch University, Murdoch WA 6150 (Australia)
  2. Disease Investigation Centre, PO Box 3322, Denpasar, Bali (Indonesia)
Publication Date:
OSTI Identifier:
21357557
Resource Type:
Journal Article
Journal Name:
Virology
Additional Journal Information:
Journal Volume: 393; Journal Issue: 2; Other Information: DOI: 10.1016/j.virol.2009.07.027; PII: S0042-6822(09)00458-9; Copyright (c) 2009 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Journal ID: ISSN 0042-6822
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ANTIGENS; CATTLE; DISEASES; IMMUNOGLOBULINS; IMMUNOSUPPRESSION; IN VIVO; LUNGS; LYMPHOCYTES; MACROPHAGES; PATHOGENESIS; PLASMA CELLS; PROLIFERATION; VIRUSES; ANIMAL CELLS; ANIMALS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DOMESTIC ANIMALS; GLOBULINS; LEUKOCYTES; MAMMALS; MATERIALS; MICROORGANISMS; ORGANIC COMPOUNDS; ORGANS; PARASITES; PHAGOCYTES; PROTEINS; RESPIRATORY SYSTEM; RUMINANTS; SOMATIC CELLS; VERTEBRATES

Citation Formats

Desport, Moira, Tenaya, I.W. Masa, Disease Investigation Centre, PO Box 3322, Denpasar, Bali, McLachlan, Alexander, McNab, Tegan J, Rachmat, Judhi, Hartaningsih, Nining, and Wilcox, Graham E. In vivo infection of IgG-containing cells by Jembrana disease virus during acute infection. United States: N. p., 2009. Web. doi:10.1016/j.virol.2009.07.027.
Desport, Moira, Tenaya, I.W. Masa, Disease Investigation Centre, PO Box 3322, Denpasar, Bali, McLachlan, Alexander, McNab, Tegan J, Rachmat, Judhi, Hartaningsih, Nining, & Wilcox, Graham E. In vivo infection of IgG-containing cells by Jembrana disease virus during acute infection. United States. https://doi.org/10.1016/j.virol.2009.07.027
Desport, Moira, Tenaya, I.W. Masa, Disease Investigation Centre, PO Box 3322, Denpasar, Bali, McLachlan, Alexander, McNab, Tegan J, Rachmat, Judhi, Hartaningsih, Nining, and Wilcox, Graham E. 2009. "In vivo infection of IgG-containing cells by Jembrana disease virus during acute infection". United States. https://doi.org/10.1016/j.virol.2009.07.027.
@article{osti_21357557,
title = {In vivo infection of IgG-containing cells by Jembrana disease virus during acute infection},
author = {Desport, Moira and Tenaya, I.W. Masa and Disease Investigation Centre, PO Box 3322, Denpasar, Bali and McLachlan, Alexander and McNab, Tegan J and Rachmat, Judhi and Hartaningsih, Nining and Wilcox, Graham E},
abstractNote = {Jembrana disease virus (JDV) is an unusual bovine lentivirus which causes a non-follicular proliferation of lymphocytes, a transient immunosuppression and a delayed humoral response in infected Bali cattle in Indonesia. A double-immunofluorescent labeling method was developed to identify the subset of mononuclear cells in which the viral capsid protein could be detected. Viral antigen was present in pleomorphic centroblast-like cells which were identified as IgG-containing cells, including plasma cells, in lymphoid tissues. There was no evidence of infection of CD3{sup +} T-cells or MAC387{sup +} monocytes in tissues but large vacuolated cells with a macrophage-like morphology in the lung were found to contain viral antigen although they could not be shown conclusively to be infected. The tropism of JDV for mature IgG-containing cells may be relevant to understanding the pathogenesis of Jembrana disease, the delayed antibody responses and the genetic composition of this atypical lentivirus.},
doi = {10.1016/j.virol.2009.07.027},
url = {https://www.osti.gov/biblio/21357557}, journal = {Virology},
issn = {0042-6822},
number = 2,
volume = 393,
place = {United States},
year = {Sun Oct 25 00:00:00 EDT 2009},
month = {Sun Oct 25 00:00:00 EDT 2009}
}