Low-Energy Grazing Ion-Scattering From Alkali-Halide Surfaces: A Novel Approach To C-14 Detection
- Physics Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6372 (United States)
- Australian Nuclear Science and Technology Organization, PMB1, Menai, NSW 2234 (Australia)
Carbon-14 labeled compounds are widely used in the pharmaceutical industry, e.g., as tracers to determine the fate of these compounds in vivo. Conventional accelerator mass spectrometry (AMS) is one approach that offers sufficiently high sensitivity to avoid radiological waste and contamination issues in such studies, but requires large, expensive facilities that are usually not solely dedicated to this task. At the ORNL Multicharged Ion Research Facility (MIRF) we are exploring a small size, low cost alternative to AMS for biomedical {sup 14}C tracer studies that utilizes ECR-ion-source-generated keV-energy-range multicharged C beams grazingly incident on an alkali halide target, where efficient negative ion production by multiple electron capture takes place. By using C ion charge states of +3 or higher, the molecular isobar interference at mass 14, e.g. {sup 12}CH{sub 2} and {sup 13}CH, is eliminated. The negatively charged ions in the beam scattered from the alkali halide surface are separated from other scattered charge states by two large acceptance ({approx}15 msr) stages of electrostatic analysis. The N-14 isobar interference is thus removed, since N does not support a stable negative ion. Initial results for C-14 detection obtained using C-14 enriched CO{sub 2} from ANSTO will be described.
- OSTI ID:
- 21289541
- Journal Information:
- AIP Conference Proceedings, Vol. 1099, Issue 1; Conference: CAARI 2008: 12. international conference on application of accelerators in research and industry, Fort Worth, TX (United States), 10-15 Aug 2008; Other Information: DOI: 10.1063/1.3120038; (c) 2009 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA); ISSN 0094-243X
- Country of Publication:
- United States
- Language:
- English
Similar Records
Electron capture from occupied surface states within the band gap of LiF(100)
On the neutralization of singly and multicharged projectiles during grazing interactions with LiF(100)