Dosimetric Parameters in Partial Breast Irradiation Through Brachytherapy

Gloi, Aime; McCourt, Steve; Buchanan, Robert; Goetller, Andrea; Zuge, Corrie; Balzoa, Paula; Cooley, Greg

doi:10.1016/j.meddos.2008.08.003

Title: Dosimetric Parameters in Partial Breast Irradiation Through Brachytherapy

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Abstract

The objective of this work is to evaluate biological models and dose homogeneity in a new partial breast irradiation method, the MammoSite RTS. The study is based on 11 patients who received the therapy. For each patient, we determined the dose volume distribution delivered to the breast. Based on these data, we estimate some important biological parameters. Eleven patients with early-stage, invasive, ductal breast cancer were treated using MammoSite RTS brachytherapy, which delivers radiation through a balloon placed in the lumpectomy bed. The radiation was provided by an Iridium-192 source, and 340 cGy were delivered per fraction twice daily. We calculated some commonly used dosimetric parameters, and evaluated the biological parameters tumor control probability (TCP) and normal tissue complication probability (NTCP). We also looked for correlations among these parameters. The average equivalent uniform dose (EUD), NTCP, and TCP were 43.66 Gy, 47.95%, and 91.78%, respectively. The coefficient of variation (CV) among the patients was very low for all 3 parameters. Two dose homogeneity indices (DHI and the S-index) are strongly correlated (r = -0.815). The area under the dose-volume histogram (DVH) and the treatment volume (TXV) also showed a strong correlation (r = 0.995, p < 0.0001). A simplified logitmore »« less

Authors:

Gloi, Aime ^[1]; McCourt, Steve; Buchanan, Robert; Goetller, Andrea; Zuge, Corrie; Balzoa, Paula; Cooley, Greg ^[1]

Department of Radiation Oncology, St. Vincent, Green Bay, WI (United States)

Publication Date:: Thu Oct 01 00:00:00 EDT 2009

OSTI Identifier:: 21286852

Resource Type:: Journal Article

Journal Name:: Medical Dosimetry

Additional Journal Information:: Journal Volume: 34; Journal Issue: 3; Other Information: DOI: 10.1016/j.meddos.2008.08.003; PII: S0958-3947(08)00132-5; Copyright (c) 2009 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0958-3947

Country of Publication:: United States

Language:: English

Subject:: 61 RADIATION PROTECTION AND DOSIMETRY; BIOLOGICAL MODELS; BRACHYTHERAPY; IRIDIUM 192; MAMMARY GLANDS; NEOPLASMS; RADIATION DOSES

Citation Formats


                    Gloi, Aime, McCourt, Steve, Buchanan, Robert, Goetller, Andrea, Zuge, Corrie, Balzoa, Paula, and Cooley, Greg. Dosimetric Parameters in Partial Breast Irradiation Through Brachytherapy.  United States: N. p., 2009. 
        Web.  doi:10.1016/j.meddos.2008.08.003.

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                    Gloi, Aime, McCourt, Steve, Buchanan, Robert, Goetller, Andrea, Zuge, Corrie, Balzoa, Paula, & Cooley, Greg. Dosimetric Parameters in Partial Breast Irradiation Through Brachytherapy.  United States.  https://doi.org/10.1016/j.meddos.2008.08.003

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                    Gloi, Aime, McCourt, Steve, Buchanan, Robert, Goetller, Andrea, Zuge, Corrie, Balzoa, Paula, and Cooley, Greg. 2009.  
        "Dosimetric Parameters in Partial Breast Irradiation Through Brachytherapy".  United States.  https://doi.org/10.1016/j.meddos.2008.08.003.

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@article{osti_21286852,

  title        = {Dosimetric Parameters in Partial Breast Irradiation Through Brachytherapy},

  author       = {Gloi, Aime and McCourt, Steve and Buchanan, Robert and Goetller, Andrea and Zuge, Corrie and Balzoa, Paula and Cooley, Greg},

  abstractNote = {The objective of this work is to evaluate biological models and dose homogeneity in a new partial breast irradiation method, the MammoSite RTS. The study is based on 11 patients who received the therapy. For each patient, we determined the dose volume distribution delivered to the breast. Based on these data, we estimate some important biological parameters. Eleven patients with early-stage, invasive, ductal breast cancer were treated using MammoSite RTS brachytherapy, which delivers radiation through a balloon placed in the lumpectomy bed. The radiation was provided by an Iridium-192 source, and 340 cGy were delivered per fraction twice daily. We calculated some commonly used dosimetric parameters, and evaluated the biological parameters tumor control probability (TCP) and normal tissue complication probability (NTCP). We also looked for correlations among these parameters. The average equivalent uniform dose (EUD), NTCP, and TCP were 43.66 Gy, 47.95%, and 91.78%, respectively. The coefficient of variation (CV) among the patients was very low for all 3 parameters. Two dose homogeneity indices (DHI and the S-index) are strongly correlated (r = -0.815). The area under the dose-volume histogram (DVH) and the treatment volume (TXV) also showed a strong correlation (r = 0.995, p < 0.0001). A simplified logit Poisson-EUD model is suitable for determining NTCP and TCP. Other factors such as the area under the DVH and dose homogeneity indices are also useful in planning radiotherapy treatments for early breast cancer.},

  doi          = {10.1016/j.meddos.2008.08.003},

  url          = {https://www.osti.gov/biblio/21286852},
  journal      = {Medical Dosimetry},

  issn         = {0958-3947},

  number       = 3,

  volume       = 34,

  place        = {United States},

  year         = {Thu Oct 01 00:00:00 EDT 2009},

  month        = {Thu Oct 01 00:00:00 EDT 2009}

}

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