skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Neoadjuvant Treatment Does Not Influence Perioperative Outcome in Rectal Cancer Surgery

Abstract

Purpose: To identify the risk factors for perioperative morbidity in patients undergoing resection of primary rectal cancer, with a specific focus on the effect of neoadjuvant therapy. Methods and Materials: This exploratory analysis of prospectively collected data included all patients who underwent anterior resection/low anterior resection or abdominoperineal resection for primary rectal cancer between October 2001 and October 2006. The study endpoints were perioperative surgical and medical morbidity. Univariate and multivariate analyses of potential risk factors were performed. Results: A total of 485 patients were included in this study; 425 patients (88%) underwent a sphincter-saving anterior resection/low anterior resection, 47 (10%) abdominoperineal resection, and 13 (2%) multivisceral resection. Neoadjuvant chemoradiotherapy was performed in 100 patients (21%), and 168 (35%) underwent neoadjuvant short-term radiotherapy (5 x 5 Gy). Patient age and operative time were independently associated with perioperative morbidity, and operative time, body mass index >27 kg/m{sup 2} (overweight), and resection type were associated with surgical morbidity. Age and a history of smoking were confirmed as independent prognostic risk factors for medical complications. Neoadjuvant therapy was not associated with a worse outcome. Conclusion: The results of this prospective study have identified several risk factors associated with an adverse perioperative outcome aftermore » rectal cancer surgery. In addition, neoadjuvant therapy was not associated with increased perioperative complications.« less

Authors:
 [1];  [1]; ;  [1];  [2];  [3];  [1]
  1. Department of Surgery, University of Heidelberg, Heidelberg (Germany)
  2. Nationales Centrum fuer Tumorerkrankungen, University of Heidelberg, Heidelberg (Germany)
  3. Department of Clinical Radiology, Radiooncology and Radiotherapy, University of Heidelberg, Heidelberg (Germany)
Publication Date:
OSTI Identifier:
21282003
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 75; Journal Issue: 1; Other Information: DOI: 10.1016/j.ijrobp.2008.10.051; PII: S0360-3016(08)03732-2; Copyright (c) 2009 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; COMBINED THERAPY; DISEASE INCIDENCE; HAZARDS; MULTIVARIATE ANALYSIS; NEOPLASMS; PATIENTS; RADIOTHERAPY; RECTUM; SURGERY

Citation Formats

Ulrich, Alexis, Weitz, Juergen, Slodczyk, Matthias, Koch, Moritz, Jaeger, Dirk, Muenter, Marc, and Buechler, Markus W. Neoadjuvant Treatment Does Not Influence Perioperative Outcome in Rectal Cancer Surgery. United States: N. p., 2009. Web. doi:10.1016/j.ijrobp.2008.10.051.
Ulrich, Alexis, Weitz, Juergen, Slodczyk, Matthias, Koch, Moritz, Jaeger, Dirk, Muenter, Marc, & Buechler, Markus W. Neoadjuvant Treatment Does Not Influence Perioperative Outcome in Rectal Cancer Surgery. United States. https://doi.org/10.1016/j.ijrobp.2008.10.051
Ulrich, Alexis, Weitz, Juergen, Slodczyk, Matthias, Koch, Moritz, Jaeger, Dirk, Muenter, Marc, and Buechler, Markus W. 2009. "Neoadjuvant Treatment Does Not Influence Perioperative Outcome in Rectal Cancer Surgery". United States. https://doi.org/10.1016/j.ijrobp.2008.10.051.
@article{osti_21282003,
title = {Neoadjuvant Treatment Does Not Influence Perioperative Outcome in Rectal Cancer Surgery},
author = {Ulrich, Alexis and Weitz, Juergen and Slodczyk, Matthias and Koch, Moritz and Jaeger, Dirk and Muenter, Marc and Buechler, Markus W},
abstractNote = {Purpose: To identify the risk factors for perioperative morbidity in patients undergoing resection of primary rectal cancer, with a specific focus on the effect of neoadjuvant therapy. Methods and Materials: This exploratory analysis of prospectively collected data included all patients who underwent anterior resection/low anterior resection or abdominoperineal resection for primary rectal cancer between October 2001 and October 2006. The study endpoints were perioperative surgical and medical morbidity. Univariate and multivariate analyses of potential risk factors were performed. Results: A total of 485 patients were included in this study; 425 patients (88%) underwent a sphincter-saving anterior resection/low anterior resection, 47 (10%) abdominoperineal resection, and 13 (2%) multivisceral resection. Neoadjuvant chemoradiotherapy was performed in 100 patients (21%), and 168 (35%) underwent neoadjuvant short-term radiotherapy (5 x 5 Gy). Patient age and operative time were independently associated with perioperative morbidity, and operative time, body mass index >27 kg/m{sup 2} (overweight), and resection type were associated with surgical morbidity. Age and a history of smoking were confirmed as independent prognostic risk factors for medical complications. Neoadjuvant therapy was not associated with a worse outcome. Conclusion: The results of this prospective study have identified several risk factors associated with an adverse perioperative outcome after rectal cancer surgery. In addition, neoadjuvant therapy was not associated with increased perioperative complications.},
doi = {10.1016/j.ijrobp.2008.10.051},
url = {https://www.osti.gov/biblio/21282003}, journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 1,
volume = 75,
place = {United States},
year = {Tue Sep 01 00:00:00 EDT 2009},
month = {Tue Sep 01 00:00:00 EDT 2009}
}