O-GlcNAc inhibits interaction between Sp1 and Elf-1 transcription factors

Journal Article · Fri Mar 13 00:00:00 EDT 2009 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/j.bbrc.2009.01.121· OSTI ID:21255928

Lim, Kihong ^[1]; Chang, Hyo-Ihl ^[1]

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1. School of Life Sciences and Biotechnology, Korea University, 5-1 Anam-dong, Seongbuk-gu, Seoul 136-701 (Korea, Republic of)

The novel protein modification, O-linked N-acetylglucosamine (O-GlcNAc), plays an important role in various aspects of cell regulation. Although most of nuclear transcription regulatory factors are modified by O-GlcNAc, O-GlcNAc effects on transcription remain largely undefined yet. In this study, we show that O-GlcNAc inhibits a physical interaction between Sp1 and Elf-1 transcription factors, and negatively regulates transcription of placenta and embryonic expression oncofetal protein gene (Pem). These findings suggest that O-GlcNAc inhibits Sp1-mediated gene transcription possibly by interrupting Sp1 interaction with its cooperative factor.

• OSTI ID: 21255928
• Journal Information: Biochemical and Biophysical Research Communications, Vol. 380, Issue 3; Other Information: DOI: 10.1016/j.bbrc.2009.01.121; PII: S0006-291X(09)00168-5; Copyright (c) 2009 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
GENES
INTERACTIONS
PLACENTA
TRANSCRIPTION
TRANSCRIPTION FACTORS