Isoflurane and desflurane at clinically relevant concentrations induce amyloid {beta}-peptide oligomerization: An NMR study

Fodale, Vincenzo

doi:10.1016/j.bbrc.2008.12.092

Title: Isoflurane and desflurane at clinically relevant concentrations induce amyloid {beta}-peptide oligomerization: An NMR study

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Abstract

Current understanding on Alzheimer's disease (AD) reveals that soluble amyloid {beta}-peptide (A{beta}) oligomeric formation plays an important role in AD pathophysiology. A potential role for several inhaled anesthetics in promoting A{beta} oligomer formation has been suggested. Using a nuclear magnetic resonance (NMR) study, we previously demonstrated that at a high concentration (higher than clinically relevant concentrations), the inhaled anesthetics halothane and isoflurane, interact with specific amino acid residues (G29, A30, and I31) and induce A{beta} oligomerization. The present study confirms this is true at a clinically relevant concentration. Isoflurane and desflurane induce A{beta} oligomerization by inducing chemical shift changes of the critical amino acid residues (G29, A30, and I31), reinforcing the evidence that perturbation of these three crucial residues indeed plays an important role in oligomerization. These findings support the emerging hypothesis that several commonly used inhaled anesthetics could be involved in neurodegeneration, as well as risk factor for accelerating the onset of AD.

Authors:

Fodale, Vincenzo ^[1]

Department of Neurosciences, Psychiatric and Anesthesiological Sciences, University of Messina, Policlinico G. Martino, Via C. Valeria, I-98125 Messina (Italy)

Publication Date:: Fri Feb 13 00:00:00 EST 2009

OSTI Identifier:: 21255878

Resource Type:: Journal Article

Journal Name:: Biochemical and Biophysical Research Communications

Additional Journal Information:: Journal Volume: 379; Journal Issue: 3; Other Information: DOI: 10.1016/j.bbrc.2008.12.092; PII: S0006-291X(08)02488-1; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0006-291X

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES; AMINO ACIDS; ANESTHETICS; CHEMICAL SHIFT; NERVOUS SYSTEM DISEASES; NUCLEAR MAGNETIC RESONANCE; PEPTIDES; PERTURBATION THEORY

Citation Formats


                    Mandal, Pravat K, and Fodale, Vincenzo. Isoflurane and desflurane at clinically relevant concentrations induce amyloid {beta}-peptide oligomerization: An NMR study.  United States: N. p., 2009. 
        Web.  doi:10.1016/j.bbrc.2008.12.092.

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                    Mandal, Pravat K, & Fodale, Vincenzo. Isoflurane and desflurane at clinically relevant concentrations induce amyloid {beta}-peptide oligomerization: An NMR study.  United States.  https://doi.org/10.1016/j.bbrc.2008.12.092

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                    Mandal, Pravat K, and Fodale, Vincenzo. 2009.  
        "Isoflurane and desflurane at clinically relevant concentrations induce amyloid {beta}-peptide oligomerization: An NMR study".  United States.  https://doi.org/10.1016/j.bbrc.2008.12.092.

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@article{osti_21255878,

  title        = {Isoflurane and desflurane at clinically relevant concentrations induce amyloid {beta}-peptide oligomerization: An NMR study},

  author       = {Mandal, Pravat K and Fodale, Vincenzo},

  abstractNote = {Current understanding on Alzheimer's disease (AD) reveals that soluble amyloid {beta}-peptide (A{beta}) oligomeric formation plays an important role in AD pathophysiology. A potential role for several inhaled anesthetics in promoting A{beta} oligomer formation has been suggested. Using a nuclear magnetic resonance (NMR) study, we previously demonstrated that at a high concentration (higher than clinically relevant concentrations), the inhaled anesthetics halothane and isoflurane, interact with specific amino acid residues (G29, A30, and I31) and induce A{beta} oligomerization. The present study confirms this is true at a clinically relevant concentration. Isoflurane and desflurane induce A{beta} oligomerization by inducing chemical shift changes of the critical amino acid residues (G29, A30, and I31), reinforcing the evidence that perturbation of these three crucial residues indeed plays an important role in oligomerization. These findings support the emerging hypothesis that several commonly used inhaled anesthetics could be involved in neurodegeneration, as well as risk factor for accelerating the onset of AD.},

  doi          = {10.1016/j.bbrc.2008.12.092},

  url          = {https://www.osti.gov/biblio/21255878},
  journal      = {Biochemical and Biophysical Research Communications},

  issn         = {0006-291X},

  number       = 3,

  volume       = 379,

  place        = {United States},

  year         = {Fri Feb 13 00:00:00 EST 2009},

  month        = {Fri Feb 13 00:00:00 EST 2009}

}

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