Interspecies extrapolation for mammals and birds: What`s a risk assessor to do?
- Environmental Protection Agency, Washington, DC (United States)
- Harvard School of Public Health, Boston, MA (United States)
Ecological risk assessors are often faced with the need to extrapolate laboratory data on a particular species to another species of interest. For aquatic organisms, an extensive database is available that has been used to develop empirical intertaxa extrapolation factors. For birds and mammals, however, such a database does not exist. This presentation explores the strengths and limitations of using knowledge of allometric scaling to address issues of interspecies differences in toxic response. In particular, the authors focus on approaches for oral exposure. Most approaches to interspecies extrapolation begin with implicit or explicit assumptions about how to express equivalent doses for different body sizes. It is in these calculations that knowledge of allometric scaling has its greatest applicability. Options include adjusting dose for equivalent organ weights (i.e., approximately BW{sup 1}), equivalent surface area (i.e., approximately BW{sup 2/3}), or equivalent metabolic rate (i.e., approximately BW{sup 3/4}). The authors will discuss the basis for each of these options, precedents for their use, and implications for analyzing ecotoxicological data.
- OSTI ID:
- 212009
- Report Number(s):
- CONF-9511137-; ISBN 1-880611-03-1; TRN: IM9617%%325
- Resource Relation:
- Conference: 2. Society of Environmental Toxicology and Chemistry (SETAC) world conference, Vancouver (Canada), 5-9 Nov 1995; Other Information: PBD: 1995; Related Information: Is Part Of Second SETAC world congress (16. annual meeting): Abstract book. Global environmental protection: Science, politics, and common sense; PB: 378 p.
- Country of Publication:
- United States
- Language:
- English
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