Papillomavirus DNA replication - From initiation to genomic instability
- Institute of Technology, University of Tartu, Nooruse 1, Tartu 50411 (Estonia)
Papillomaviruses establish their productive life cycle in stratified epithelium or mucosa, where the undifferentiated proliferating keratinocytes are the initial targets for the productive viral infection. Papillomaviruses have evolved mechanisms to adapt to the normal cellular growth control pathways and to adjust their DNA replication and maintenance cycle to contend with the cellular differentiation. We provide overview of the papillomavirus DNA replication in the differentiating epithelium and describe the molecular interactions important for viral DNA replication on all steps of the viral life cycle.
- OSTI ID:
- 21182806
- Journal Information:
- Virology, Vol. 384, Issue 2; Other Information: DOI: 10.1016/j.virol.2008.11.032; PII: S0042-6822(08)00769-1; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0042-6822
- Country of Publication:
- United States
- Language:
- English
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