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Title: The tale of a modern animal plague: Tracing the evolutionary history and determining the time-scale for foot and mouth disease virus

Abstract

Despite significant advances made in the understanding of its epidemiology, foot and mouth disease virus (FMDV) is among the most unexpected agricultural devastating plagues. While the disease manifests itself as seven immunologically distinct strains their origin, population dynamics, migration patterns and divergence times remain unknown. Herein we have assembled a comprehensive data set of gene sequences representing the global diversity of the disease and inferred the time-scale and evolutionary history for FMDV. Serotype-specific rates of evolution and divergence times were estimated using a Bayesian coalescent framework. We report that an ancient precursor FMDV gave rise to two major diversification events spanning a relatively short interval of time. This radiation event is estimated to have taken place towards the end of the 17th and the beginning of the 18th century giving us the present circulating Euro-Asiatic and South African viral strains. Furthermore our results hint that Europe acted as a possible hub for the disease from where it successfully dispersed elsewhere via exploration and trading routes.

Authors:
 [1];  [2]
  1. Smurfit Institute of Genetics, Trinity College Dublin (Ireland), E-mail: dtully@tcd.ie
  2. Smurfit Institute of Genetics, Trinity College Dublin (Ireland), E-mail: faresm@tcd.ie
Publication Date:
OSTI Identifier:
21182789
Resource Type:
Journal Article
Journal Name:
Virology
Additional Journal Information:
Journal Volume: 382; Journal Issue: 2; Other Information: DOI: 10.1016/j.virol.2008.09.011; PII: S0042-6822(08)00591-6; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0042-6822
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; DIVERSIFICATION; EPIDEMIOLOGY; FEET; GENETIC VARIABILITY; ORAL CAVITY; POPULATION DYNAMICS; VIRAL DISEASES; VIRUSES

Citation Formats

Tully, Damien C., and Fares, Mario A. The tale of a modern animal plague: Tracing the evolutionary history and determining the time-scale for foot and mouth disease virus. United States: N. p., 2008. Web. doi:10.1016/j.virol.2008.09.011.
Tully, Damien C., & Fares, Mario A. The tale of a modern animal plague: Tracing the evolutionary history and determining the time-scale for foot and mouth disease virus. United States. https://doi.org/10.1016/j.virol.2008.09.011
Tully, Damien C., and Fares, Mario A. 2008. "The tale of a modern animal plague: Tracing the evolutionary history and determining the time-scale for foot and mouth disease virus". United States. https://doi.org/10.1016/j.virol.2008.09.011.
@article{osti_21182789,
title = {The tale of a modern animal plague: Tracing the evolutionary history and determining the time-scale for foot and mouth disease virus},
author = {Tully, Damien C. and Fares, Mario A.},
abstractNote = {Despite significant advances made in the understanding of its epidemiology, foot and mouth disease virus (FMDV) is among the most unexpected agricultural devastating plagues. While the disease manifests itself as seven immunologically distinct strains their origin, population dynamics, migration patterns and divergence times remain unknown. Herein we have assembled a comprehensive data set of gene sequences representing the global diversity of the disease and inferred the time-scale and evolutionary history for FMDV. Serotype-specific rates of evolution and divergence times were estimated using a Bayesian coalescent framework. We report that an ancient precursor FMDV gave rise to two major diversification events spanning a relatively short interval of time. This radiation event is estimated to have taken place towards the end of the 17th and the beginning of the 18th century giving us the present circulating Euro-Asiatic and South African viral strains. Furthermore our results hint that Europe acted as a possible hub for the disease from where it successfully dispersed elsewhere via exploration and trading routes.},
doi = {10.1016/j.virol.2008.09.011},
url = {https://www.osti.gov/biblio/21182789}, journal = {Virology},
issn = {0042-6822},
number = 2,
volume = 382,
place = {United States},
year = {Sat Dec 20 00:00:00 EST 2008},
month = {Sat Dec 20 00:00:00 EST 2008}
}