Polycyclic aromatic hydrocarbon-DNA adducts and survival among women with breast cancer
- Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC (United States)
- Global Epidemiology, Pfizer Inc., New York, NY (United States)
- Department of Community Health and Prevention, Mt. Sinai School of Medicine, New York, NY (United States)
- Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY (United States)
- Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY (United States)
Polycyclic aromatic hydrocarbons (PAH) are mammary carcinogens in animal studies, and a few epidemiologic studies have suggested a link between elevated levels of PAH-DNA adducts and breast cancer incidence. An association between PAH-DNA adducts and survival among breast cancer cases has not been previously reported. We conducted a survival analysis among women with newly diagnosed invasive breast cancer between 1996 and 1997, enrolled in the Long Island Breast Cancer Study Project. DNA was isolated from blood samples that were obtained from cases shortly after diagnosis and assayed for PAH-DNA adducts using ELISA. Among the 722 cases with PAH-DNA adduct measurements, 97 deaths (13.4%) from all causes and 54 deaths (7.5%) due to breast cancer were reported to National Death Index (NDI) by December 31, 2002. Using Cox proportional hazards models and controlling for age at diagnosis, we did not find evidence that all-cause mortality (hazard ratio (HR)=0.88; 95% confidence interval (CI): 0.57-1.37), or breast cancer mortality (HR=1.20; 95% CI: 0.63-2.28) was strongly associated with detectable PAH-DNA adduct levels compared with non-detectable adducts; additionally, no dose-response association was observed. Among a subgroup with treatment data (n=520), adducts were associated with over a two-fold higher mortality among those receiving radiation, but mortality for adducts was reduced among hormone therapy users. Results from this large population-based study do not provide strong support for an association between detectable PAH-DNA adducts and survival among women with breast cancer, except perhaps among those receiving radiation treatment.
- OSTI ID:
- 21176124
- Journal Information:
- Environmental Research, Vol. 109, Issue 3; Other Information: DOI: 10.1016/j.envres.2008.11.005; PII: S0013-9351(08)00256-9; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0013-9351
- Country of Publication:
- United States
- Language:
- English
Similar Records
Delay in initiating adjuvant radiotherapy following breast conservation surgery and its impact on survival
Breast Cancer Mortality vs. Exercise and Breast Size in Runners and Walkers