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Title: Investigation of hepatic fibrosis in rats with x-ray diffraction enhanced imaging

Abstract

X-ray diffraction enhanced imaging (DEI) is a phase contrast technique that generates excellent contrast of biological soft tissues compared to conventional absorption radiography. We explore the application of DEI in the diagnosis of hepatic fibrosis. The produced refraction contrast images of fibrous rat liver samples show clearly abnormal liver architectures. Moreover, by comparing to histological pictures, different stages of fibrosis are discriminated, and the corresponding morphological features are analyzed. Besides, quantitative analyses of texture features are presented. The results reported herein show that DEI can be a potential noninvasive technique to diagnose and stage hepatic fibrosis.

Authors:
 [1]; ; ;  [1];  [2]; ;  [3]
  1. School of Biomedical Engineering, Capital Medical University, Beijing 100069 (China)
  2. Department of Pathology, China-Japan Friendship Hospital, Beijing 100029 (China)
  3. Liver Research Center, Beijing Friendship Hospital, Beijing 100050 (China)
Publication Date:
OSTI Identifier:
21176064
Resource Type:
Journal Article
Journal Name:
Applied Physics Letters
Additional Journal Information:
Journal Volume: 94; Journal Issue: 12; Other Information: DOI: 10.1063/1.3104860; (c) 2009 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0003-6951
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ABSORPTION; BIOMEDICAL RADIOGRAPHY; DIAGNOSIS; FIBROSIS; IMAGE PROCESSING; IMAGES; LIVER; RATS; REFRACTION; TEXTURE; X-RAY DIFFRACTION

Citation Formats

Hui, Li, Department of Medical Physics, Peking University Health Science Center, Beijing 100191, Lu, Zhang, Xueyan, Wang, Shuqian, Luo, Tailing, Wang, Baoen, Wang, and Xinyan, Zhao. Investigation of hepatic fibrosis in rats with x-ray diffraction enhanced imaging. United States: N. p., 2009. Web. doi:10.1063/1.3104860.
Hui, Li, Department of Medical Physics, Peking University Health Science Center, Beijing 100191, Lu, Zhang, Xueyan, Wang, Shuqian, Luo, Tailing, Wang, Baoen, Wang, & Xinyan, Zhao. Investigation of hepatic fibrosis in rats with x-ray diffraction enhanced imaging. United States. https://doi.org/10.1063/1.3104860
Hui, Li, Department of Medical Physics, Peking University Health Science Center, Beijing 100191, Lu, Zhang, Xueyan, Wang, Shuqian, Luo, Tailing, Wang, Baoen, Wang, and Xinyan, Zhao. 2009. "Investigation of hepatic fibrosis in rats with x-ray diffraction enhanced imaging". United States. https://doi.org/10.1063/1.3104860.
@article{osti_21176064,
title = {Investigation of hepatic fibrosis in rats with x-ray diffraction enhanced imaging},
author = {Hui, Li and Department of Medical Physics, Peking University Health Science Center, Beijing 100191 and Lu, Zhang and Xueyan, Wang and Shuqian, Luo and Tailing, Wang and Baoen, Wang and Xinyan, Zhao},
abstractNote = {X-ray diffraction enhanced imaging (DEI) is a phase contrast technique that generates excellent contrast of biological soft tissues compared to conventional absorption radiography. We explore the application of DEI in the diagnosis of hepatic fibrosis. The produced refraction contrast images of fibrous rat liver samples show clearly abnormal liver architectures. Moreover, by comparing to histological pictures, different stages of fibrosis are discriminated, and the corresponding morphological features are analyzed. Besides, quantitative analyses of texture features are presented. The results reported herein show that DEI can be a potential noninvasive technique to diagnose and stage hepatic fibrosis.},
doi = {10.1063/1.3104860},
url = {https://www.osti.gov/biblio/21176064}, journal = {Applied Physics Letters},
issn = {0003-6951},
number = 12,
volume = 94,
place = {United States},
year = {Mon Mar 23 00:00:00 EDT 2009},
month = {Mon Mar 23 00:00:00 EDT 2009}
}