On the Path to Seeking Novel Radiosensitizers

Journal Article · Sun Mar 15 00:00:00 EDT 2009 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2008.12.002· OSTI ID:21172655

Katz, David; Ito, Emma ^[1]; Feifei, Liu ^[1]

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1. Department of Medical Biophysics, University of Toronto, Toronto, ON (Canada)

Radiation therapy is a highly effective cancer treatment modality, and extensive investigations have been undertaken over the years to augment its efficacy in the clinic. This review summarizes the current understanding of the biologic bases underpinning many of the clinically used radiosensitizers. In addition, this review illustrates how the advent of innovative, high-throughput technologies with integration of different disciplines could be harnessed for an expeditious discovery process for novel radiosensitizers, providing an exciting future for such pursuits in radiation biology and oncology.

• OSTI ID: 21172655
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Vol. 73, Issue 4; Other Information: DOI: 10.1016/j.ijrobp.2008.12.002; PII: S0360-3016(08)03811-X; Copyright (c) 2009 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ANOXIA
CARCINOMAS
RADIOSENSITIZERS
RADIOTHERAPY
REVIEWS
SENSITIZERS