Hedgehog-mediated paracrine interaction between hepatic stellate cells and marrow-derived mesenchymal stem cells
- Division of Hepatology, Third Hospital of Sun Yat-Sen University, Tianhe Road 600, Guangzhou City 510630, Guangdong Province (China)
- Center for Stem Cell Biology and Tissue Engineering, Sun Yat-Sen University, Guangzhou City, Guangdong Province (China)
During liver injury, bone marrow-derived mesenchymal stem cells (MSCs) can migrate and differentiate into hepatocytes. Hepatic stellate cell (SC) activation is a pivotal event in the development of liver fibrosis. Therefore, we hypothesized that SCs may play an important role in regulating MSC proliferation and differentiation through the paracrine signaling pathway. We demonstrate that MSCs and SCs both express hedgehog (Hh) pathway components, including its ligands, receptors, and target genes. Transwell co-cultures of SCs and MSCs showed that the SCs produced sonic hedgehog (Shh), which enhanced the proliferation and differentiation of MSCs. These findings demonstrate that SCs indirectly modulate the activity of MSCs in vitro via the Hh pathway, and provide a plausible explanation for the mechanisms of transplanted MSCs in the treatment of liver fibrosis.
- OSTI ID:
- 21143778
- Journal Information:
- Biochemical and Biophysical Research Communications, Vol. 372, Issue 1; Other Information: DOI: 10.1016/j.bbrc.2008.05.029; PII: S0006-291X(08)00935-2; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
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