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Title: Influence of Pro-Qura-generated Plans on Postimplant Dosimetric Quality: A Review of a Multi-Institutional Database

Abstract

The influence of Pro-Qura-generated plans vs. community-generated plans on postprostate brachytherapy dosimetric quality was compared. In the Pro-Qura database, 2933 postplans were evaluated from 57 institutions. A total of 1803 plans were generated by Pro-Qura and 1130 by community institutions. Iodine-125 ({sup 125}I) plans outnumbered Palladium 103 ({sup 103}Pd) plans by a ratio of 3:1. Postimplant dosimetry was performed in a standardized fashion by overlapping the preimplant ultrasound and the postimplant computed tomography (CT). In this analysis, adequacy was defined as a V{sub 100} > 80% and a D{sub 90} of 90% to 140% for both isotopes along with a V{sub 150} < 60% for {sup 125}I and < 75% for {sup 103}Pd. The mean postimplant V{sub 100} and D{sub 90} were 88.6% and 101.6% vs. 89.3% and 102.3% for Pro-Qura and community plans, respectively. When analyzed in terms of the first 8 sequence groups (10 patients/sequence group) for each institution, Pro-Qura planning resulted in less postimplant variability for V{sub 100} (86.2-89.5%) and for D{sub 90} (97.4-103.2%) while community-generated plans had greater V{sub 100} (85.3-91.2%) and D{sub 90} (95.9-105.2%) ranges. In terms of sequence groups, postimplant dosimetry was deemed 'too cool' in 11% to 30% of cases and 'too hot'more » in 12% to 27%. On average, no clinically significant postimplant dosimetric differences were discerned between Pro-Qura and community-based planning. However, substantially greater variability was identified in the community-based plan cohort. It is possible that the Pro-Qura plan and/or the routine postimplant dosimetric evaluation may have influenced dosimetric outcomes at community-based centers.« less

Authors:
 [1];  [1]; ; ; ; ; ;  [1]
  1. Wheeling Hospital, Schiffler Cancer Center, Wheeling, WV (United States)
Publication Date:
OSTI Identifier:
21140788
Resource Type:
Journal Article
Journal Name:
Medical Dosimetry
Additional Journal Information:
Journal Volume: 33; Journal Issue: 3; Other Information: DOI: 10.1016/j.meddos.2007.09.001; PII: S0958-3947(07)00159-8; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0958-3947
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRACHYTHERAPY; COMPUTERIZED TOMOGRAPHY; DOSIMETRY; EVALUATION; IODINE 125; PALLADIUM 103; PATIENTS; PLANNING; PROSTATE; REVIEWS

Citation Formats

Allen, Zachariah, Wheeling Jesuit University, Wheeling, WV, Seattle Prostate Institute, Seattle, WA, Pro-Qura, Seattle, WA, Merrick, Gregory S, Wheeling Jesuit University, Wheeling, WV, Seattle Prostate Institute, Seattle, WA, Pro-Qura, Seattle, WA, Grimm, Peter, Blasko, John, Sylvester, John, Butler, Wayne, Chaudry, Usman-Ul-Haq, Sitter, Michael, Wheeling Jesuit University, Wheeling, WV, Seattle Prostate Institute, Seattle, WA, and Pro-Qura, Seattle, WA. Influence of Pro-Qura-generated Plans on Postimplant Dosimetric Quality: A Review of a Multi-Institutional Database. United States: N. p., 2008. Web. doi:10.1016/j.meddos.2007.09.001.
Allen, Zachariah, Wheeling Jesuit University, Wheeling, WV, Seattle Prostate Institute, Seattle, WA, Pro-Qura, Seattle, WA, Merrick, Gregory S, Wheeling Jesuit University, Wheeling, WV, Seattle Prostate Institute, Seattle, WA, Pro-Qura, Seattle, WA, Grimm, Peter, Blasko, John, Sylvester, John, Butler, Wayne, Chaudry, Usman-Ul-Haq, Sitter, Michael, Wheeling Jesuit University, Wheeling, WV, Seattle Prostate Institute, Seattle, WA, & Pro-Qura, Seattle, WA. Influence of Pro-Qura-generated Plans on Postimplant Dosimetric Quality: A Review of a Multi-Institutional Database. United States. https://doi.org/10.1016/j.meddos.2007.09.001
Allen, Zachariah, Wheeling Jesuit University, Wheeling, WV, Seattle Prostate Institute, Seattle, WA, Pro-Qura, Seattle, WA, Merrick, Gregory S, Wheeling Jesuit University, Wheeling, WV, Seattle Prostate Institute, Seattle, WA, Pro-Qura, Seattle, WA, Grimm, Peter, Blasko, John, Sylvester, John, Butler, Wayne, Chaudry, Usman-Ul-Haq, Sitter, Michael, Wheeling Jesuit University, Wheeling, WV, Seattle Prostate Institute, Seattle, WA, and Pro-Qura, Seattle, WA. 2008. "Influence of Pro-Qura-generated Plans on Postimplant Dosimetric Quality: A Review of a Multi-Institutional Database". United States. https://doi.org/10.1016/j.meddos.2007.09.001.
@article{osti_21140788,
title = {Influence of Pro-Qura-generated Plans on Postimplant Dosimetric Quality: A Review of a Multi-Institutional Database},
author = {Allen, Zachariah and Wheeling Jesuit University, Wheeling, WV and Seattle Prostate Institute, Seattle, WA and Pro-Qura, Seattle, WA and Merrick, Gregory S and Wheeling Jesuit University, Wheeling, WV and Seattle Prostate Institute, Seattle, WA and Pro-Qura, Seattle, WA and Grimm, Peter and Blasko, John and Sylvester, John and Butler, Wayne and Chaudry, Usman-Ul-Haq and Sitter, Michael and Wheeling Jesuit University, Wheeling, WV and Seattle Prostate Institute, Seattle, WA and Pro-Qura, Seattle, WA},
abstractNote = {The influence of Pro-Qura-generated plans vs. community-generated plans on postprostate brachytherapy dosimetric quality was compared. In the Pro-Qura database, 2933 postplans were evaluated from 57 institutions. A total of 1803 plans were generated by Pro-Qura and 1130 by community institutions. Iodine-125 ({sup 125}I) plans outnumbered Palladium 103 ({sup 103}Pd) plans by a ratio of 3:1. Postimplant dosimetry was performed in a standardized fashion by overlapping the preimplant ultrasound and the postimplant computed tomography (CT). In this analysis, adequacy was defined as a V{sub 100} > 80% and a D{sub 90} of 90% to 140% for both isotopes along with a V{sub 150} < 60% for {sup 125}I and < 75% for {sup 103}Pd. The mean postimplant V{sub 100} and D{sub 90} were 88.6% and 101.6% vs. 89.3% and 102.3% for Pro-Qura and community plans, respectively. When analyzed in terms of the first 8 sequence groups (10 patients/sequence group) for each institution, Pro-Qura planning resulted in less postimplant variability for V{sub 100} (86.2-89.5%) and for D{sub 90} (97.4-103.2%) while community-generated plans had greater V{sub 100} (85.3-91.2%) and D{sub 90} (95.9-105.2%) ranges. In terms of sequence groups, postimplant dosimetry was deemed 'too cool' in 11% to 30% of cases and 'too hot' in 12% to 27%. On average, no clinically significant postimplant dosimetric differences were discerned between Pro-Qura and community-based planning. However, substantially greater variability was identified in the community-based plan cohort. It is possible that the Pro-Qura plan and/or the routine postimplant dosimetric evaluation may have influenced dosimetric outcomes at community-based centers.},
doi = {10.1016/j.meddos.2007.09.001},
url = {https://www.osti.gov/biblio/21140788}, journal = {Medical Dosimetry},
issn = {0958-3947},
number = 3,
volume = 33,
place = {United States},
year = {Wed Oct 01 00:00:00 EDT 2008},
month = {Wed Oct 01 00:00:00 EDT 2008}
}