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Title: Catheterization of the Hepatic Artery Via the Left Common Carotid Artery in Rats

Abstract

The commonly used approach for rat hepatic artery catheterization is via the gastroduodenal artery, which is ligated after the procedure. A new method of rat hepatic artery catheterization via the left common carotid artery (LCCA) is described. The LCCA is repaired after catheterization. The catheterization procedures included the following: (1) opening the rat's abdominal cavity and exposing the portion of abdominal aorta at the level of the celiac trunk; (2) separating and exposing the LCCA; inserting a microguidewire and microcatheter set into the LCCA via an incision; after placement into the descending aorta, the microguidewire and microcatheter are maneuvered into the hepatic artery under direct vision; (3) after transcatheter therapy, the catheter is withdrawn and the incision at the LCCA is repaired. This technique was employed on 60 male Sprague-Dawley rats with diethylnitrosamine-induced liver cancer, using a 3F microguidewire and microcatheter set. Selective hepatic artery catheterization was successfully performed in 57 rats. One rat died during the operation and five rats died within 7 days after the procedure. It is envisaged that as experience increases, the catheterization success rate will increase and the death rate will decrease. A new approach for selective hepatic artery catheterization via the LCCA in ratsmore » is introduced, which makes repeat catheterization of this artery possible and allows large embolization particles to be delivered by using a 3F catheter.« less

Authors:
 [1];  [2]; ;  [3]
  1. West China Hospital, Sichuan University, Department of Radiology (China)
  2. AstraZeneca R and D (United Kingdom)
  3. West China Hospital, Sichuan University, Department of Gastroenterology (China)
Publication Date:
OSTI Identifier:
21091082
Resource Type:
Journal Article
Journal Name:
Cardiovascular and Interventional Radiology
Additional Journal Information:
Journal Volume: 29; Journal Issue: 6; Other Information: DOI: 10.1007/s00270-005-8268-3; Copyright (c) 2006 Springer Science+Business Media, Inc.; www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0174-1551
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; AORTA; CAROTID ARTERIES; DEATH; LIVER; NEOPLASMS; RATS; THERAPY

Citation Formats

Xiao, Li, Wang Yixiang, J, Zhou Xiangping, Yongsong, Guan, and Chengwei, Tang. Catheterization of the Hepatic Artery Via the Left Common Carotid Artery in Rats. United States: N. p., 2006. Web. doi:10.1007/S00270-005-8268-3.
Xiao, Li, Wang Yixiang, J, Zhou Xiangping, Yongsong, Guan, & Chengwei, Tang. Catheterization of the Hepatic Artery Via the Left Common Carotid Artery in Rats. United States. https://doi.org/10.1007/S00270-005-8268-3
Xiao, Li, Wang Yixiang, J, Zhou Xiangping, Yongsong, Guan, and Chengwei, Tang. 2006. "Catheterization of the Hepatic Artery Via the Left Common Carotid Artery in Rats". United States. https://doi.org/10.1007/S00270-005-8268-3.
@article{osti_21091082,
title = {Catheterization of the Hepatic Artery Via the Left Common Carotid Artery in Rats},
author = {Xiao, Li and Wang Yixiang, J and Zhou Xiangping and Yongsong, Guan and Chengwei, Tang},
abstractNote = {The commonly used approach for rat hepatic artery catheterization is via the gastroduodenal artery, which is ligated after the procedure. A new method of rat hepatic artery catheterization via the left common carotid artery (LCCA) is described. The LCCA is repaired after catheterization. The catheterization procedures included the following: (1) opening the rat's abdominal cavity and exposing the portion of abdominal aorta at the level of the celiac trunk; (2) separating and exposing the LCCA; inserting a microguidewire and microcatheter set into the LCCA via an incision; after placement into the descending aorta, the microguidewire and microcatheter are maneuvered into the hepatic artery under direct vision; (3) after transcatheter therapy, the catheter is withdrawn and the incision at the LCCA is repaired. This technique was employed on 60 male Sprague-Dawley rats with diethylnitrosamine-induced liver cancer, using a 3F microguidewire and microcatheter set. Selective hepatic artery catheterization was successfully performed in 57 rats. One rat died during the operation and five rats died within 7 days after the procedure. It is envisaged that as experience increases, the catheterization success rate will increase and the death rate will decrease. A new approach for selective hepatic artery catheterization via the LCCA in rats is introduced, which makes repeat catheterization of this artery possible and allows large embolization particles to be delivered by using a 3F catheter.},
doi = {10.1007/S00270-005-8268-3},
url = {https://www.osti.gov/biblio/21091082}, journal = {Cardiovascular and Interventional Radiology},
issn = {0174-1551},
number = 6,
volume = 29,
place = {United States},
year = {Fri Dec 15 00:00:00 EST 2006},
month = {Fri Dec 15 00:00:00 EST 2006}
}