Experimental Study on Transarterial Administration of GRGDSP Combined with Transarterial Chemoembolization in Rats with Hepatic Carcinoma
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Department of Radiology (China)
Purpose. To evaluate the effects of transarterial administration of an integrin antagonist, GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro), combined with transarterial chemoembolization (TACE) to treat hepatic carcinoma in rats. Methods. Walker-256 tumor was implanted beneath the liver capsule in 26 Wistar rats. Animal subjects were assigned to groups based on which treatment was injected into the hepatic artery: group A, GRGDSP + TACE; group B, TACE alone; and group C, normal saline. Magnetic resonance imaging (MRI), tumor pathology, and immunohistochemistry were performed to assess each treatment. Results. The ratios of the post-treatment to pretreatment tumor volumes (V2/V1) in groups A, B, and C were 4.42 {+-} 0.48, 6.98 {+-} 1.09, and 13.00 {+-} 1.68, respectively. The metastatic potential of the tumors was assessed by tumor cell nest counts, which were 5.00 {+-} 1.25, 6.63 {+-} 1.60, and 7.22 {+-} 1.92 in groups A, B, and C, respectively. Microvessel density (MVD) was quantified by measuring von Willebrand factor density values, which were 0.18 {+-} 0.02, 0.22 {+-} 0.02, and 0.23 {+-} 0.02 in groups A, B, and C, respectively. Conclusions. Transarterial infusion of GRGDSP combined with TACE noticeably inhibited the growth of hepatic carcinoma and intrahepatic metastases in rats.
- OSTI ID:
- 21090631
- Journal Information:
- Cardiovascular and Interventional Radiology, Vol. 31, Issue 2; Other Information: DOI: 10.1007/s00270-007-9233-0; Copyright (c) 2008 Springer Science+Business Media, LLC; Country of input: International Atomic Energy Agency (IAEA); ISSN 0174-1551
- Country of Publication:
- United States
- Language:
- English
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