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Title: Efficacy of Local Molsidomine Delivery from a Hydrogel-Coated Angioplasty Balloon Catheter in the Atherosclerotic Porcine Model

Abstract

Purpose: To evaluate the therapeutic effects of local molsidomine delivery via a hydrogel-coated angioplasty balloon catheter during overstretch angioplasty in atheroscleroticswine iliac vessels. Molsidomine is retained in the arterial wall after local delivery for more than 72 hr and is slowly metabolized intolinsidomine, releasing nitric oxide (NO). Methods: A hydrogel-coated angioplasty balloon catheter was used to both deliver drug locally (150 mg molsidomine or placebo in the contralateral vessel) and dilate iliac vessels in nine Pietrin pigs that had been on an atherogenic diet for 5 months. Animals were killed at 3 hr(n = 2), 24 hr (n = 3) and 3 months(n = 3) after treatment. Iliac arteries were examined for wall pulsatility, histomorphometry, cell proliferation and platelet aggregation. Results: No significant therapeutic effects were detected 3 hr after treatment. At 24 hr, wall pulsatility,thrombo resistance and vascular cell homeostasis were significantly restored in the molsidomine-treated versus placebo group. At 3 months,molsidomine inhibited restenotic lesion development, except in scarred areas of histologically detectable adventitial/medial dissection. Conclusion: Local delivery of concentrated molsidomine from a hydrogel-coated angioplasty balloon catheter resulted in early NO-dependent vasodilation/stress normalization and antithrombotic and antiproliferative effects. In the medium term, molsidomine inhibited restenosis in the absence ofmore » vessel dissection.« less

Authors:
;  [1];  [2]; ; ; ;  [1]
  1. School of Medicine, Faculte de Medicine, 27, Hemodynamics and Cardiovascular Mechanics Laboratory, Bld Jean-Moulin, F-13385 Marseille Cedex 5 (France)
  2. Boston Scientific Corporation, 1 Boston Scientific Place, Natick, MA 01760 (United States)
Publication Date:
OSTI Identifier:
21088429
Resource Type:
Journal Article
Journal Name:
Cardiovascular and Interventional Radiology
Additional Journal Information:
Journal Volume: 26; Journal Issue: 1; Other Information: DOI: 10.1007/s00270-002-1940-y; Copyright (c) 2002 Springer-Verlag New York, Inc; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0174-1551
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ARTERIES; CELL PROLIFERATION; DIET; HOMEOSTASIS; HYDROGELS; NITRIC OXIDE; SWINE; VASODILATION

Citation Formats

Rolland, Pierre H, Mekkaoui, Choukri, Palassi, Maria, Friggi, Alain, Moulin, Guy, Piquet, Philippe, and Bartoli, Jean-Michel. Efficacy of Local Molsidomine Delivery from a Hydrogel-Coated Angioplasty Balloon Catheter in the Atherosclerotic Porcine Model. United States: N. p., 2003. Web. doi:10.1007/S00270-002-1940-Y.
Rolland, Pierre H, Mekkaoui, Choukri, Palassi, Maria, Friggi, Alain, Moulin, Guy, Piquet, Philippe, & Bartoli, Jean-Michel. Efficacy of Local Molsidomine Delivery from a Hydrogel-Coated Angioplasty Balloon Catheter in the Atherosclerotic Porcine Model. United States. https://doi.org/10.1007/S00270-002-1940-Y
Rolland, Pierre H, Mekkaoui, Choukri, Palassi, Maria, Friggi, Alain, Moulin, Guy, Piquet, Philippe, and Bartoli, Jean-Michel. 2003. "Efficacy of Local Molsidomine Delivery from a Hydrogel-Coated Angioplasty Balloon Catheter in the Atherosclerotic Porcine Model". United States. https://doi.org/10.1007/S00270-002-1940-Y.
@article{osti_21088429,
title = {Efficacy of Local Molsidomine Delivery from a Hydrogel-Coated Angioplasty Balloon Catheter in the Atherosclerotic Porcine Model},
author = {Rolland, Pierre H and Mekkaoui, Choukri and Palassi, Maria and Friggi, Alain and Moulin, Guy and Piquet, Philippe and Bartoli, Jean-Michel},
abstractNote = {Purpose: To evaluate the therapeutic effects of local molsidomine delivery via a hydrogel-coated angioplasty balloon catheter during overstretch angioplasty in atheroscleroticswine iliac vessels. Molsidomine is retained in the arterial wall after local delivery for more than 72 hr and is slowly metabolized intolinsidomine, releasing nitric oxide (NO). Methods: A hydrogel-coated angioplasty balloon catheter was used to both deliver drug locally (150 mg molsidomine or placebo in the contralateral vessel) and dilate iliac vessels in nine Pietrin pigs that had been on an atherogenic diet for 5 months. Animals were killed at 3 hr(n = 2), 24 hr (n = 3) and 3 months(n = 3) after treatment. Iliac arteries were examined for wall pulsatility, histomorphometry, cell proliferation and platelet aggregation. Results: No significant therapeutic effects were detected 3 hr after treatment. At 24 hr, wall pulsatility,thrombo resistance and vascular cell homeostasis were significantly restored in the molsidomine-treated versus placebo group. At 3 months,molsidomine inhibited restenotic lesion development, except in scarred areas of histologically detectable adventitial/medial dissection. Conclusion: Local delivery of concentrated molsidomine from a hydrogel-coated angioplasty balloon catheter resulted in early NO-dependent vasodilation/stress normalization and antithrombotic and antiproliferative effects. In the medium term, molsidomine inhibited restenosis in the absence of vessel dissection.},
doi = {10.1007/S00270-002-1940-Y},
url = {https://www.osti.gov/biblio/21088429}, journal = {Cardiovascular and Interventional Radiology},
issn = {0174-1551},
number = 1,
volume = 26,
place = {United States},
year = {Sat Feb 15 00:00:00 EST 2003},
month = {Sat Feb 15 00:00:00 EST 2003}
}