skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Intense Inflammatory Reaction to Heparin Polymer Coated Intravascular Palmaz Stents in Porcine Arteries Compared to Uncoated Palmaz Stents

Abstract

The objective of this study was to evaluate the efficacy of heparin-polymer-coated intravascular stents in the reduction of vessel stenosis. Three types of coatings for Palmaz stents were tested: 1) heparin covalently bound to a polyethylene oxide(Hp-PEO) tether; 2) heparin copolymerized with ethylene vinyl acetate(Hp-Elvax) and 3) Elvax alone. Polymer-coated stents and uncoated controls were deployed in the external iliac arteries following endothelial injury in 18 swine. The animals were maintained on anatherogenic diet and examined by angiography at 6 and 12 weeks. The stented segments were then harvested for histopathologic analysis. Both types of heparin-coated stents resulted in increased luminal narrowing as compared to the contralateral uncoated stents. At 6 weeks, average luminal stenosis was 48% for Hp-PEO stents vs 35% for uncoated stents (p < 0.05). At 12 weeks, average luminal stenosis was 36% for Hp-PEO stents vs 26% for uncoated stents(p = NS). For Hp-Elvax stents, the average stenosis was 58% vs 33% for uncoated controls (p <0.05) at 6 weeks and 47% vs 19% for uncoated controls(p < 0.05) at 12 weeks. There was no significant difference between Hp-Elvax stents and Elvax stents(p = NS). Increased luminal narrowing in coated stents was primarily secondary to amore » marked inflammatory response.Heparin-polyethylene oxide and heparin-ethylene vinyl acetate-coated stents resulted in increased luminal narrowing as compared with uncoated stents, due to a marked inflammatory response.« less

Authors:
 [1]; ; ; ; ; ;  [2]
  1. Veterans Administration, Los Angeles, CA, Department of Radiology (United States)
  2. UCLA School of Medicine, Los Angeles, CA, Department ofRadiological Science (United States)
Publication Date:
OSTI Identifier:
21088409
Resource Type:
Journal Article
Journal Name:
Cardiovascular and Interventional Radiology
Additional Journal Information:
Journal Volume: 26; Journal Issue: 2; Other Information: DOI: 10.1007/s00270-002-2562-0; Copyright (c) 2003 Springer-Verlag New York, Inc.; www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0174-1551
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ARTERIES; BIOMEDICAL RADIOGRAPHY; ETHYLENE; HEPARIN; INFLAMMATION; PHENOBARBITAL; POLYETHYLENE GLYCOLS; SWINE; VINYL ACETATE

Citation Formats

Goodwin, Scott C, Yoon, Hyo-Chun, Chen, Gary, Abdel-Sayed, Peter, Costantino, Mary M, Bonilla, Sheila M, and Nishimura, Earl. Intense Inflammatory Reaction to Heparin Polymer Coated Intravascular Palmaz Stents in Porcine Arteries Compared to Uncoated Palmaz Stents. United States: N. p., 2003. Web. doi:10.1007/S00270-002-2562-0.
Goodwin, Scott C, Yoon, Hyo-Chun, Chen, Gary, Abdel-Sayed, Peter, Costantino, Mary M, Bonilla, Sheila M, & Nishimura, Earl. Intense Inflammatory Reaction to Heparin Polymer Coated Intravascular Palmaz Stents in Porcine Arteries Compared to Uncoated Palmaz Stents. United States. https://doi.org/10.1007/S00270-002-2562-0
Goodwin, Scott C, Yoon, Hyo-Chun, Chen, Gary, Abdel-Sayed, Peter, Costantino, Mary M, Bonilla, Sheila M, and Nishimura, Earl. 2003. "Intense Inflammatory Reaction to Heparin Polymer Coated Intravascular Palmaz Stents in Porcine Arteries Compared to Uncoated Palmaz Stents". United States. https://doi.org/10.1007/S00270-002-2562-0.
@article{osti_21088409,
title = {Intense Inflammatory Reaction to Heparin Polymer Coated Intravascular Palmaz Stents in Porcine Arteries Compared to Uncoated Palmaz Stents},
author = {Goodwin, Scott C and Yoon, Hyo-Chun and Chen, Gary and Abdel-Sayed, Peter and Costantino, Mary M and Bonilla, Sheila M and Nishimura, Earl},
abstractNote = {The objective of this study was to evaluate the efficacy of heparin-polymer-coated intravascular stents in the reduction of vessel stenosis. Three types of coatings for Palmaz stents were tested: 1) heparin covalently bound to a polyethylene oxide(Hp-PEO) tether; 2) heparin copolymerized with ethylene vinyl acetate(Hp-Elvax) and 3) Elvax alone. Polymer-coated stents and uncoated controls were deployed in the external iliac arteries following endothelial injury in 18 swine. The animals were maintained on anatherogenic diet and examined by angiography at 6 and 12 weeks. The stented segments were then harvested for histopathologic analysis. Both types of heparin-coated stents resulted in increased luminal narrowing as compared to the contralateral uncoated stents. At 6 weeks, average luminal stenosis was 48% for Hp-PEO stents vs 35% for uncoated stents (p < 0.05). At 12 weeks, average luminal stenosis was 36% for Hp-PEO stents vs 26% for uncoated stents(p = NS). For Hp-Elvax stents, the average stenosis was 58% vs 33% for uncoated controls (p <0.05) at 6 weeks and 47% vs 19% for uncoated controls(p < 0.05) at 12 weeks. There was no significant difference between Hp-Elvax stents and Elvax stents(p = NS). Increased luminal narrowing in coated stents was primarily secondary to a marked inflammatory response.Heparin-polyethylene oxide and heparin-ethylene vinyl acetate-coated stents resulted in increased luminal narrowing as compared with uncoated stents, due to a marked inflammatory response.},
doi = {10.1007/S00270-002-2562-0},
url = {https://www.osti.gov/biblio/21088409}, journal = {Cardiovascular and Interventional Radiology},
issn = {0174-1551},
number = 2,
volume = 26,
place = {United States},
year = {Tue Apr 15 00:00:00 EDT 2003},
month = {Tue Apr 15 00:00:00 EDT 2003}
}