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Title: Radiofrequency Ablation of Lung Malignancies: Where Do We Stand?

Abstract

Percutaneous radiofrequency (RF) ablation is a minimally invasive technique used to treat solid tumors. Because of its ability to produce large volumes of coagulation necrosis in a controlled fashion, this technique has gained acceptance as a viable therapeutic option for unresectable liver malignancies. Recently, investigation has been focused on the clinical application of RF ablation in the treatment of lung malignancies. In theory, lung tumors are well suited to RF ablation because the surrounding air in adjacent normal parenchyma provides an insulating effect, thus facilitating energy concentration within the tumor tissue. Experimental studies in rabbits have confirmed that lung RF ablation can be safely and effectively performed via a percutaneous, transthoracic approach, and have prompted the start of clinical investigation. Pilot clinical studies have shown that RF ablation enables successful treatment of relatively small lung malignancies with a high rate of complete response and acceptable morbidity, and have suggested that the technique could represent a viable alternate or complementary treatment method for patients with non-small cell lung cancer or lung metastases of favorable histotypes who are not candidates for surgical resection. This article gives an overview of lung RF ablation, discussing experimental animal findings, rationale for clinical application, technique andmore » methodology, clinical results, and complications.« less

Authors:
; ;  [1];  [2];  [3];  [2]; ;  [1];  [2]; ;  [4];  [2];  [1]
  1. University of Pisa, Division of Diagnostic and Interventional Radiology, Department of Oncology, Transplants, and Advanced Technologies in Medicine (Italy)
  2. University of Pisa, Division of Thoracic Surgery, Cardiac and Thoracic Department (Italy)
  3. University of Pisa, Division of Pathology, Department of Oncology, Transplants, and Advanced Technologies in Medicine (Italy)
  4. Cisanello University Hospital, Division of Anesthesiology (Italy)
Publication Date:
OSTI Identifier:
21088184
Resource Type:
Journal Article
Journal Name:
Cardiovascular and Interventional Radiology
Additional Journal Information:
Journal Volume: 27; Journal Issue: 6; Other Information: DOI: 10.1007/s00270-004-0008-6; Copyright (c) 2004 Springer-Verlag New York, LLC; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0174-1551
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ABLATION; LIVER; LUNGS; METASTASES; NECROSIS; NEOPLASMS; PATIENTS; RABBITS; RADIOWAVE RADIATION; SURGERY

Citation Formats

Lencioni, Riccardo, Crocetti, Laura, Cioni, Roberto, Mussi, Alfredo, Fontanini, Gabriella, Ambrogi, Marcello, Franchini, Chiara, Cioni, Dania, Fanucchi, Olivia, Gemignani, Raffaello, Baldassarri, Rubia, Angeletti, Carlo Alberto, and Bartolozzi, Carlo. Radiofrequency Ablation of Lung Malignancies: Where Do We Stand?. United States: N. p., 2004. Web. doi:10.1007/S00270-004-0008-6.
Lencioni, Riccardo, Crocetti, Laura, Cioni, Roberto, Mussi, Alfredo, Fontanini, Gabriella, Ambrogi, Marcello, Franchini, Chiara, Cioni, Dania, Fanucchi, Olivia, Gemignani, Raffaello, Baldassarri, Rubia, Angeletti, Carlo Alberto, & Bartolozzi, Carlo. Radiofrequency Ablation of Lung Malignancies: Where Do We Stand?. United States. https://doi.org/10.1007/S00270-004-0008-6
Lencioni, Riccardo, Crocetti, Laura, Cioni, Roberto, Mussi, Alfredo, Fontanini, Gabriella, Ambrogi, Marcello, Franchini, Chiara, Cioni, Dania, Fanucchi, Olivia, Gemignani, Raffaello, Baldassarri, Rubia, Angeletti, Carlo Alberto, and Bartolozzi, Carlo. 2004. "Radiofrequency Ablation of Lung Malignancies: Where Do We Stand?". United States. https://doi.org/10.1007/S00270-004-0008-6.
@article{osti_21088184,
title = {Radiofrequency Ablation of Lung Malignancies: Where Do We Stand?},
author = {Lencioni, Riccardo and Crocetti, Laura and Cioni, Roberto and Mussi, Alfredo and Fontanini, Gabriella and Ambrogi, Marcello and Franchini, Chiara and Cioni, Dania and Fanucchi, Olivia and Gemignani, Raffaello and Baldassarri, Rubia and Angeletti, Carlo Alberto and Bartolozzi, Carlo},
abstractNote = {Percutaneous radiofrequency (RF) ablation is a minimally invasive technique used to treat solid tumors. Because of its ability to produce large volumes of coagulation necrosis in a controlled fashion, this technique has gained acceptance as a viable therapeutic option for unresectable liver malignancies. Recently, investigation has been focused on the clinical application of RF ablation in the treatment of lung malignancies. In theory, lung tumors are well suited to RF ablation because the surrounding air in adjacent normal parenchyma provides an insulating effect, thus facilitating energy concentration within the tumor tissue. Experimental studies in rabbits have confirmed that lung RF ablation can be safely and effectively performed via a percutaneous, transthoracic approach, and have prompted the start of clinical investigation. Pilot clinical studies have shown that RF ablation enables successful treatment of relatively small lung malignancies with a high rate of complete response and acceptable morbidity, and have suggested that the technique could represent a viable alternate or complementary treatment method for patients with non-small cell lung cancer or lung metastases of favorable histotypes who are not candidates for surgical resection. This article gives an overview of lung RF ablation, discussing experimental animal findings, rationale for clinical application, technique and methodology, clinical results, and complications.},
doi = {10.1007/S00270-004-0008-6},
url = {https://www.osti.gov/biblio/21088184}, journal = {Cardiovascular and Interventional Radiology},
issn = {0174-1551},
number = 6,
volume = 27,
place = {United States},
year = {Mon Nov 15 00:00:00 EST 2004},
month = {Mon Nov 15 00:00:00 EST 2004}
}