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Title: Transcatheter Arterial Embolization for Malignant Osseous and Soft-Tissue Sarcomas. I. A Rabbit Experimental Model

Abstract

Purpose: To evaluate the effect of transcatheter arterial embolization (TAE) on metastatic bone tumors in an experimental study. Methods: Fifteen Japanese white rabbits were transplanted with VX2 sarcoma cells into the iliac crest. In 10 rabbits, the arterial supply to the iliac bone tumors, internal iliac artery and iliolumbar artery were then embolized with particles of gelatin sponge. The therapeutic effect was evaluated by comparison with the natural course of control tumors in the other five rabbits. Results: After TAE, extensive necrosis, fibrosis, and vacuolization within the tumors were confirmed histologically. In the control rabbits, 19% {+-} 7% of the entire tumor was found to be spontaneous tumor necrosis; in contrast, the tumors of the TAE group showed necrosis as 62% {+-} 22% of the entire tumor. In one TAE group rabbit, no active tumor cell could be detected in the residual tumor. Conclusion: TAE was found to be an effective treatment for bone tumors in an experimental model.

Authors:
; ; ; ; ; ; ;  [1]; ;  [2]
  1. Department of Radiology, Kyoto University Hospital, Sakyo Kyoto 606-8507 (Japan)
  2. Department of Orthopedics, Kyoto University Hospital, Sakyo Kyoto 606-8507 (Japan)
Publication Date:
OSTI Identifier:
21080404
Resource Type:
Journal Article
Journal Name:
Cardiovascular and Interventional Radiology
Additional Journal Information:
Journal Volume: 21; Journal Issue: 3; Other Information: DOI: 10.1007/s002709900245; Copyright (c) 1996 Springer-Verlag New York Inc; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0174-1551
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ARTERIES; FIBROSIS; GELATIN; METASTASES; NECROSIS; RABBITS; SARCOMAS; SKELETON; TUMOR CELLS

Citation Formats

Nagata, Yasushi, Fujiwara, Kazuhisa, Okajima, Kaoru, Mitsumori, Michihide, Mizowaki, Takashi, Ohya, Natsuo, Hiraoka, Masahiro, Abe, Mitsuyuki, Ohura, Koitirou, and Wataya, Shigeki. Transcatheter Arterial Embolization for Malignant Osseous and Soft-Tissue Sarcomas. I. A Rabbit Experimental Model. United States: N. p., 1998. Web. doi:10.1007/S002709900245.
Nagata, Yasushi, Fujiwara, Kazuhisa, Okajima, Kaoru, Mitsumori, Michihide, Mizowaki, Takashi, Ohya, Natsuo, Hiraoka, Masahiro, Abe, Mitsuyuki, Ohura, Koitirou, & Wataya, Shigeki. Transcatheter Arterial Embolization for Malignant Osseous and Soft-Tissue Sarcomas. I. A Rabbit Experimental Model. United States. https://doi.org/10.1007/S002709900245
Nagata, Yasushi, Fujiwara, Kazuhisa, Okajima, Kaoru, Mitsumori, Michihide, Mizowaki, Takashi, Ohya, Natsuo, Hiraoka, Masahiro, Abe, Mitsuyuki, Ohura, Koitirou, and Wataya, Shigeki. 1998. "Transcatheter Arterial Embolization for Malignant Osseous and Soft-Tissue Sarcomas. I. A Rabbit Experimental Model". United States. https://doi.org/10.1007/S002709900245.
@article{osti_21080404,
title = {Transcatheter Arterial Embolization for Malignant Osseous and Soft-Tissue Sarcomas. I. A Rabbit Experimental Model},
author = {Nagata, Yasushi and Fujiwara, Kazuhisa and Okajima, Kaoru and Mitsumori, Michihide and Mizowaki, Takashi and Ohya, Natsuo and Hiraoka, Masahiro and Abe, Mitsuyuki and Ohura, Koitirou and Wataya, Shigeki},
abstractNote = {Purpose: To evaluate the effect of transcatheter arterial embolization (TAE) on metastatic bone tumors in an experimental study. Methods: Fifteen Japanese white rabbits were transplanted with VX2 sarcoma cells into the iliac crest. In 10 rabbits, the arterial supply to the iliac bone tumors, internal iliac artery and iliolumbar artery were then embolized with particles of gelatin sponge. The therapeutic effect was evaluated by comparison with the natural course of control tumors in the other five rabbits. Results: After TAE, extensive necrosis, fibrosis, and vacuolization within the tumors were confirmed histologically. In the control rabbits, 19% {+-} 7% of the entire tumor was found to be spontaneous tumor necrosis; in contrast, the tumors of the TAE group showed necrosis as 62% {+-} 22% of the entire tumor. In one TAE group rabbit, no active tumor cell could be detected in the residual tumor. Conclusion: TAE was found to be an effective treatment for bone tumors in an experimental model.},
doi = {10.1007/S002709900245},
url = {https://www.osti.gov/biblio/21080404}, journal = {Cardiovascular and Interventional Radiology},
issn = {0174-1551},
number = 3,
volume = 21,
place = {United States},
year = {Fri May 15 00:00:00 EDT 1998},
month = {Fri May 15 00:00:00 EDT 1998}
}