Effect on Intimal Hyperplasia of Dexamethasone Released from Coated Metal Stents Compared with Non-Coated Stents in Canine Femoral Arteries
- Department of Radiology, Diakonissen-Hospital, Diakonissenstrasse 28, D-76199 Karlsruhe (Germany)
- Department of Radiology, University Hospital, Hugstetter Strasse 55, D-79106 Freiburg (Germany)
- Department of Pharmaceutical Technology and Biopharmacy, University Heidelberg, Im Neuenheimer Feld 366, D-69120 Heidelberg (Germany)
- Department of Surgical Research, University Hospital, Breisacher Strasse 64, D-79108 Freiburg (Germany)
- Department of Pathology, University Hospital, Albertstrasse 19, D-79002 Freiburg (Germany)
- Department of Physiology, University Tuebingen, Gmelinstrasse 5, D-72076 Tuebingen (Germany)
Purpose: Polymer-coated, dexamethasone (DXM)-releasing stents were tested in order to assess the efficacy of DXM released locally for the prevention of stent restenosis due to intimal hyperplasia. Methods: Strecker stents coated with a biodegradable membrane containing DXM were implanted percutaneously into the femoral artery in 14 dogs. The contralateral artery received a conventional non-coated stent serving as control. The drugs are eluted by degradation of the carrier membrane. Follow-up intraarterial digital subtraction angiography (DSA) was obtained at 3, 6, 9, 12, and 24 weeks with subsequent autopsy. Specimens for gross and microscopic pathology were obtained and histomorphometry was performed. Results: Four of 14 DXM-coated stents showed thrombotic occlusion within the first 3 weeks; ten DXM-coated stents remained patent. At follow-up DSA, DXM-coated stents showed a significantly wider lumen than the non-coated stents. At morphometry there was less intimal hyperplasia over DXM-coated stents than over non-coated stents (p < 0.05). Conclusion: DXM-coated stents reduce neointimal hyperplasia in dogs when compared with non-coated stents.
- OSTI ID:
- 21080360
- Journal Information:
- Cardiovascular and Interventional Radiology, Vol. 21, Issue 6; Other Information: DOI: 10.1007/s002709900309; Copyright (c) 1998 Springer-Verlag New York Inc; Country of input: International Atomic Energy Agency (IAEA); ISSN 0174-1551
- Country of Publication:
- United States
- Language:
- English
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