Does Coronary Stenting Following Balloon Angioplasty Improve Myocardial Fractional Flow Reserve?

Takeuchi, Masaaki; Himeno, Etsuro

doi:10.1007/S002709900304

Title: Does Coronary Stenting Following Balloon Angioplasty Improve Myocardial Fractional Flow Reserve?

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Abstract

Purpose: Suboptimal distal coronary flow reserve after successful balloon angioplasty has been attributed to angiographically unrecognized inadequate lumen expansion, and adjunct coronary stenting has been shown to improve coronary flow reserve. The aim of this study was to investigate whether myocardial fractional flow reserve (FFRmyo) would increase further after coronary stenting compared with balloon angioplasty alone in the same patient group. Methods: FFRmyo and quantitative coronary angiography were obtained before and after pre-stent balloon dilation, and again after stent placement in 11 patients (7 left anterior descending artery, 3 right coronary artery and 1 left circumflex artery). FFRmyo was calculated as the ratio of Pd/Pa during intracoronary adenosine 5'-triphosphate (50 {mu}g and 20 {mu}g in the left and right coronary arteries, respectively)-induced maximum hyperemia, where Pd represents mean distal coronary pressure measured by a 2.1 Fr infusion catheter and Pa represents mean aortic pressure measured by the guiding catheter. Results: Percent diameter stenosis significantly decreased after balloon angioplasty (74% {+-} 15% vs 37% {+-} 17%, p < 0.001), and decreased further after stent placement (18% {+-} 10%, p < 0.001 vs baseline and balloon angioplasty). FFRmyo after coronary stenting (0.85 {+-} 0.09) was significantly higher than that at baseline (0.51more »« less

Authors:

Takeuchi, Masaaki; Himeno, Etsuro ^[1]

Second Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu (Japan)

Publication Date:: Sun Nov 15 00:00:00 EST 1998

OSTI Identifier:: 21080356

Resource Type:: Journal Article

Journal Name:: Cardiovascular and Interventional Radiology

Additional Journal Information:: Journal Volume: 21; Journal Issue: 6; Other Information: DOI: 10.1007/s002709900304; Copyright (c) 1998 Springer-Verlag New York Inc; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0174-1551

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; ADENOSINE; BALLOONS; BIOMEDICAL RADIOGRAPHY; CORONARIES; INFUSION; PATIENTS

Citation Formats


                    Takeuchi, Masaaki, and Himeno, Etsuro. Does Coronary Stenting Following Balloon Angioplasty Improve Myocardial Fractional Flow Reserve?.  United States: N. p., 1998. 
        Web.  doi:10.1007/S002709900304.

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                    Takeuchi, Masaaki, & Himeno, Etsuro. Does Coronary Stenting Following Balloon Angioplasty Improve Myocardial Fractional Flow Reserve?.  United States.  https://doi.org/10.1007/S002709900304

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                    Takeuchi, Masaaki, and Himeno, Etsuro. 1998.  
        "Does Coronary Stenting Following Balloon Angioplasty Improve Myocardial Fractional Flow Reserve?".  United States.  https://doi.org/10.1007/S002709900304.

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@article{osti_21080356,

  title        = {Does Coronary Stenting Following Balloon Angioplasty Improve Myocardial Fractional Flow Reserve?},

  author       = {Takeuchi, Masaaki and Himeno, Etsuro},

  abstractNote = {Purpose: Suboptimal distal coronary flow reserve after successful balloon angioplasty has been attributed to angiographically unrecognized inadequate lumen expansion, and adjunct coronary stenting has been shown to improve coronary flow reserve. The aim of this study was to investigate whether myocardial fractional flow reserve (FFRmyo) would increase further after coronary stenting compared with balloon angioplasty alone in the same patient group. Methods: FFRmyo and quantitative coronary angiography were obtained before and after pre-stent balloon dilation, and again after stent placement in 11 patients (7 left anterior descending artery, 3 right coronary artery and 1 left circumflex artery). FFRmyo was calculated as the ratio of Pd/Pa during intracoronary adenosine 5'-triphosphate (50 {mu}g and 20 {mu}g in the left and right coronary arteries, respectively)-induced maximum hyperemia, where Pd represents mean distal coronary pressure measured by a 2.1 Fr infusion catheter and Pa represents mean aortic pressure measured by the guiding catheter. Results: Percent diameter stenosis significantly decreased after balloon angioplasty (74% {+-} 15% vs 37% {+-} 17%, p < 0.001), and decreased further after stent placement (18% {+-} 10%, p < 0.001 vs baseline and balloon angioplasty). FFRmyo after coronary stenting (0.85 {+-} 0.09) was significantly higher than that at baseline (0.51 {+-} 0.16, p < 0.001) and after balloon angioplasty (0.77 {+-} 0.11, p < 0.05). There was a significant correlation between angiographic variables and FFRmyo. The increase in lumen dimensions after coronary stenting was followed by a further significant improvement of FFRmyo. Conclusion: These results suggest that coronary stenting may provide a more favorable functional status and lumen geometry of residual coronary stenosis compared with balloon angioplasty alone.},

  doi          = {10.1007/S002709900304},

  url          = {https://www.osti.gov/biblio/21080356},
  journal      = {Cardiovascular and Interventional Radiology},

  issn         = {0174-1551},

  number       = 6,

  volume       = 21,

  place        = {United States},

  year         = {Sun Nov 15 00:00:00 EST 1998},

  month        = {Sun Nov 15 00:00:00 EST 1998}

}

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