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Title: Dependency of tissue necrosis on gelatin sponge particle size after canine hepatic artery embolization

Abstract

Purpose. To determine the optimal size of gelatin sponge particles (GSPs) to produce maximum tumor necrosis with minimum side effects after canine hepatic artery embolization (HAE). Methods. GSPs were separated into four size ranges: A, up to 200 {mu}m (mean 152) as Gelfoam powder; B, 200-500 {mu}m (mean 336) as Gelfoam powder; C, 500-1000 {mu}m (mean 649) as Spongel; and D, 1000-2000 {mu}m (mean 1382) as Spongel. Three mongrel dogs were assigned randomly to HAE with each particle size. On day 7 after HAE, the livers were removed and subjected to pathological examination. Results. The mean volume of liver necrosis was 11% after embolization, with particle size A, 36.3% with B, 0% with C, and 1% with D. Coagulation necrosis was found in all livers with particles of sizes A and B, and in 1 of 6 with sizes C and D. Bile duct injury was found in five of six dogs with sizes A and B and in none with sizes C and D. Gallbladder necrosis was found in one dog with size B and pancreas necrosis in one with size A. Conclusion. GSPs of 500 {mu}m are considered optimally effective for tissue necrosis according to this model.

Authors:
; ; ; ; ;  [1]
  1. Wakayama Medical College, Department of Radiology (Japan)
Publication Date:
OSTI Identifier:
21080242
Resource Type:
Journal Article
Journal Name:
Cardiovascular and Interventional Radiology
Additional Journal Information:
Journal Volume: 20; Journal Issue: 1; Other Information: DOI: 10.1007/s002709900108; Copyright (c) 1997 Springer-Verlag New York Inc; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0174-1551
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ARTERIES; BILIARY TRACT; BIOMEDICAL RADIOGRAPHY; DOGS; GELATIN; INJURIES; LIVER; NECROSIS; NEOPLASMS; PANCREAS; PARTICLE SIZE; SIDE EFFECTS

Citation Formats

Sonomura, Tetsuo, Yamada, Ryusaku, Kishi, Kazushi, Nishida, Norifumi, Yang, Ren J, and Sato, Morio. Dependency of tissue necrosis on gelatin sponge particle size after canine hepatic artery embolization. United States: N. p., 1997. Web. doi:10.1007/S002709900108.
Sonomura, Tetsuo, Yamada, Ryusaku, Kishi, Kazushi, Nishida, Norifumi, Yang, Ren J, & Sato, Morio. Dependency of tissue necrosis on gelatin sponge particle size after canine hepatic artery embolization. United States. https://doi.org/10.1007/S002709900108
Sonomura, Tetsuo, Yamada, Ryusaku, Kishi, Kazushi, Nishida, Norifumi, Yang, Ren J, and Sato, Morio. 1997. "Dependency of tissue necrosis on gelatin sponge particle size after canine hepatic artery embolization". United States. https://doi.org/10.1007/S002709900108.
@article{osti_21080242,
title = {Dependency of tissue necrosis on gelatin sponge particle size after canine hepatic artery embolization},
author = {Sonomura, Tetsuo and Yamada, Ryusaku and Kishi, Kazushi and Nishida, Norifumi and Yang, Ren J and Sato, Morio},
abstractNote = {Purpose. To determine the optimal size of gelatin sponge particles (GSPs) to produce maximum tumor necrosis with minimum side effects after canine hepatic artery embolization (HAE). Methods. GSPs were separated into four size ranges: A, up to 200 {mu}m (mean 152) as Gelfoam powder; B, 200-500 {mu}m (mean 336) as Gelfoam powder; C, 500-1000 {mu}m (mean 649) as Spongel; and D, 1000-2000 {mu}m (mean 1382) as Spongel. Three mongrel dogs were assigned randomly to HAE with each particle size. On day 7 after HAE, the livers were removed and subjected to pathological examination. Results. The mean volume of liver necrosis was 11% after embolization, with particle size A, 36.3% with B, 0% with C, and 1% with D. Coagulation necrosis was found in all livers with particles of sizes A and B, and in 1 of 6 with sizes C and D. Bile duct injury was found in five of six dogs with sizes A and B and in none with sizes C and D. Gallbladder necrosis was found in one dog with size B and pancreas necrosis in one with size A. Conclusion. GSPs of 500 {mu}m are considered optimally effective for tissue necrosis according to this model.},
doi = {10.1007/S002709900108},
url = {https://www.osti.gov/biblio/21080242}, journal = {Cardiovascular and Interventional Radiology},
issn = {0174-1551},
number = 1,
volume = 20,
place = {United States},
year = {Wed Jan 15 00:00:00 EST 1997},
month = {Wed Jan 15 00:00:00 EST 1997}
}