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Title: Intervention of D-glucose ameliorates the toxicity of streptozotocin in accessory sex organs of rat

Abstract

Streptozotocin (STZ) is a naturally occurring compound isolated from Streptomyces achromogens. It is used extensively for inducing diabetes in experimental animals. Diabetes mellitus is known to have proven adverse effects on male sexual organs and their reproductive functions. The atrophy of prostate gland and other organs of the genitourinary tract were observed in experimental diabetic animals. STZ exhibits a structural resemblance to D-glucose due to the presence of sugar moiety in its structure. Pancreatic {beta}-cells mainly contain GLUT1 and GLUT2 glucose transporters. Possibly due to structural resemblance, STZ and D-glucose, share a common recognition site for entry into the {beta}-cells. The objective of the present study is to evaluate the effect of D-glucose on STZ-induced toxicity in accessory sex organs of male rats. Animals were kept on overnight fasting. One group received vehicle and served as negative control, while all other groups were given STZ (45 mg/kg). Animals that received only STZ served as positive control. The effect of D-glucose was studied on STZ treated animals with different dosage of D-glucose (250, 500, 1000 and 2000 mg/kg). Restoration of body weight, plasma glucose and plasma insulin was evident only at 1000 and 2000 mg/kg of D-glucose. The protective effect ofmore » D-glucose is evident only when it is administered simultaneously with STZ. In the present investigation, we report that simultaneous administration of D-glucose along with STZ ameliorates STZ-induced toxicity. This is evident from the restoration of accessory sex organ's weight, cellular morphology as well as insulin level.« less

Authors:
; ;  [1]
  1. Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector-67, S.A.S. Nagar, Punjab-160062 (India)
Publication Date:
OSTI Identifier:
21077889
Resource Type:
Journal Article
Journal Name:
Toxicology and Applied Pharmacology
Additional Journal Information:
Journal Volume: 226; Journal Issue: 1; Other Information: DOI: 10.1016/j.taap.2007.09.006; PII: S0041-008X(07)00413-9; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0041-008X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ATROPHY; DIABETES MELLITUS; GLUCOSE; HYPERGLYCEMIA; INSULIN; PANCREAS; PROSTATE; RATS; SACCHAROSE; STREPTOMYCES; STREPTOZOCIN; TOXICITY

Citation Formats

Vikram, A, Tripathi, D N, Ramarao, P, and Jena, G.B. Intervention of D-glucose ameliorates the toxicity of streptozotocin in accessory sex organs of rat. United States: N. p., 2008. Web. doi:10.1016/j.taap.2007.09.006.
Vikram, A, Tripathi, D N, Ramarao, P, & Jena, G.B. Intervention of D-glucose ameliorates the toxicity of streptozotocin in accessory sex organs of rat. United States. https://doi.org/10.1016/j.taap.2007.09.006
Vikram, A, Tripathi, D N, Ramarao, P, and Jena, G.B. 2008. "Intervention of D-glucose ameliorates the toxicity of streptozotocin in accessory sex organs of rat". United States. https://doi.org/10.1016/j.taap.2007.09.006.
@article{osti_21077889,
title = {Intervention of D-glucose ameliorates the toxicity of streptozotocin in accessory sex organs of rat},
author = {Vikram, A and Tripathi, D N and Ramarao, P and Jena, G.B.},
abstractNote = {Streptozotocin (STZ) is a naturally occurring compound isolated from Streptomyces achromogens. It is used extensively for inducing diabetes in experimental animals. Diabetes mellitus is known to have proven adverse effects on male sexual organs and their reproductive functions. The atrophy of prostate gland and other organs of the genitourinary tract were observed in experimental diabetic animals. STZ exhibits a structural resemblance to D-glucose due to the presence of sugar moiety in its structure. Pancreatic {beta}-cells mainly contain GLUT1 and GLUT2 glucose transporters. Possibly due to structural resemblance, STZ and D-glucose, share a common recognition site for entry into the {beta}-cells. The objective of the present study is to evaluate the effect of D-glucose on STZ-induced toxicity in accessory sex organs of male rats. Animals were kept on overnight fasting. One group received vehicle and served as negative control, while all other groups were given STZ (45 mg/kg). Animals that received only STZ served as positive control. The effect of D-glucose was studied on STZ treated animals with different dosage of D-glucose (250, 500, 1000 and 2000 mg/kg). Restoration of body weight, plasma glucose and plasma insulin was evident only at 1000 and 2000 mg/kg of D-glucose. The protective effect of D-glucose is evident only when it is administered simultaneously with STZ. In the present investigation, we report that simultaneous administration of D-glucose along with STZ ameliorates STZ-induced toxicity. This is evident from the restoration of accessory sex organ's weight, cellular morphology as well as insulin level.},
doi = {10.1016/j.taap.2007.09.006},
url = {https://www.osti.gov/biblio/21077889}, journal = {Toxicology and Applied Pharmacology},
issn = {0041-008X},
number = 1,
volume = 226,
place = {United States},
year = {Tue Jan 01 00:00:00 EST 2008},
month = {Tue Jan 01 00:00:00 EST 2008}
}