Association of urinary cadmium and myocardial infarction
- Department of Family Medicine, Medical University of South Carolina, 295 Calhoun Street, P.O. Box 250192, Charleston, SC 29425 (United States), E-mail: everettc@musc.edu
- Department of Family Medicine, Medical University of South Carolina, 295 Calhoun Street, P.O. Box 250192, Charleston, SC 29425 (United States), E-mail: frithse@musc.edu
We conducted a cross-sectional analysis of individuals 45-79 years old in the National Health and Nutrition Examination Survey III (1988-1994) (NHANES III). Myocardial infarction was determined by electrocardiogram (ECG). Our sample included 4912 participants, which when weighted represented 52,234,055 Americans. We performed adjusted logistic regressions with the Framingham risk score, pack-years of smoking, race-ethnicity, and family history of heart attack, and diabetes as covariates. Urinary cadmium {>=}0.88 {mu}g/g creatinine had an odds ratio of 1.86 (95% CI 1.26-2.75) compared to urinary cadmium <0.43 {mu}g/g creatinine. This result supports the hypothesis that cadmium is associated with coronary heart disease. When logistic regressions were done by gender, women, but not men, showed a significant association of urinary cadmium with myocardial infarction. Women with urinary cadmium {>=}0.88 {mu}g/g creatinine had an odds ratio of 1.80 (95% CI 1.06-3.04) compared to urinary cadmium <0.43 {mu}g/g creatinine. When the analysis was restricted to never smokers (N=2187) urinary cadmium {>=}0.88 {mu}g/g creatinine had an odds ratio of 1.85 (95% CI 1.10-3.14) compared to urinary cadmium <0.43 {mu}g/g creatinine.
- OSTI ID:
- 21077749
- Journal Information:
- Environmental Research, Vol. 106, Issue 2; Other Information: DOI: 10.1016/j.envres.2007.10.009; PII: S0013-9351(07)00226-5; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0013-9351
- Country of Publication:
- United States
- Language:
- English
Similar Records
Cadmium exposure in association with history of stroke and heart failure
Cadmium, follicle-stimulating hormone, and effects on bone in women age 42-60 years, NHANES III