Radiation Interaction with Therapeutic Drugs and Cell Membranes

Journal Article · Mon Apr 23 00:00:00 EDT 2007 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.2733557· OSTI ID:21057291

Martin, Diana I; Manaila, Elena N; Matei, Constantin I; Iacob, Nicusor I; Ighigeanu, Daniel I; Craciun, Gabriela D ^[1]; Moisescu, Mihaela I; Savopol, Tudor D; Kovacs, Eugenia A ^[2]; Cinca, Sabin A ^[3]; Margaritescu, Irina D ^[4]

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1. Accelerators Laboratory, National Institute for Lasers, Plasma and Radiation Physics, 409, Atomistilor St., 077125 Magurele (Romania)
2. Carol Davila University of Medicine and Pharmacy, 8, Eroii Sanitari St., 050474 Bucharest (Romania)
3. Oncology Institute Prof. A. Trestioreanu, 252, Fundeni St., 022328 Bucharest (Romania)
4. Military Clinical Hospital, 88, Mircea Vulcanescu St., 010825 Bucharest (Romania)

This transient permeabilized state of the cell membrane, named the 'cell electroporation' (CE) can be used to increase cells uptake of drugs that do not readily pass cell membrane, thus enabling their cytotoxicity. The anticancer drugs, such as bleomycin (BL) and cisplatin, are the most candidates for the combined use with ionizing and non-ionizing radiation fields. The methods and installations for the cell electroporation by electron beam (EB) and microwave (MW) irradiation are presented. The viability tests of the human leukocytes under EB and MW exposure with/without the BL in the cell cultures are discussed.

• OSTI ID: 21057291
• Journal Information: AIP Conference Proceedings, Vol. 899, Issue 1; Conference: 6. international conference of the Balkan Physical Union, Istanbul (Turkey), 22-26 Aug 2006; Other Information: DOI: 10.1063/1.2733557; (c) 2007 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA); ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLEOMYCIN
CELL CULTURES
CELL MEMBRANES
ELECTRON BEAMS
HUMAN POPULATIONS
IONIZING RADIATIONS
IRRADIATION
LEUKOCYTES
MICROWAVE RADIATION
NEOPLASMS
TRANSIENTS
UPTAKE