Surface localization of the nuclear receptor CAR in influenza A virus-infected cells

Journal Article · Fri Apr 11 00:00:00 EDT 2008 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/j.bbrc.2008.01.145· OSTI ID:21043696

Takahashi, Tadanobu ^[1]; Moriyama, Yusuke; Ikari, Akira; Sugatani, Junko ^[1]; Suzuki, Takashi ^[2]; Miwa, Masao ^[1]

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1. Department of Pharmaco-Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, and COE Program in the 21st Century, 52-1 Yada, Shizuoka 422-8526 (Japan)
2. Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, CREST, JST, and COE Program in the 21st Century, Shizuoka 422-8526 (Japan)

Constitutive active/androstane receptor CAR is a member of the nuclear receptors which regulate transcription of xenobiotic metabolism enzymes. CAR is usually localized in the cytosol and nucleus. Here, we found that CAR was localized at the cell surface of influenza A virus (IAV)-infected cells. Additionally, we demonstrated that expression of a viral envelope glycoprotein, either hemagglutinin (HA) or neuraminidase (NA), but not viral nucleoprotein (NP), was responsible for this localization. This report is the first demonstration of CAR at the surface of tissue culture cells, and suggests that CAR may exert the IAV infection mechanism.

• OSTI ID: 21043696
• Journal Information: Biochemical and Biophysical Research Communications, Vol. 368, Issue 3; Other Information: DOI: 10.1016/j.bbrc.2008.01.145; PII: S0006-291X(08)00164-2; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
CELL NUCLEI
ENZYMES
GLYCOPROTEINS
INFLUENZA
INFLUENZA VIRUSES
METABOLISM
RECEPTORS
TISSUE CULTURES
TRANSCRIPTION