Mature adipocytes may be a source of stem cells for tissue engineering
- Department of Animal Sciences, Washington State University, P.O. Box 646310, Pullman, WA 99164 (United States)
- Poultry Processing and Swine Physiology Research Unit, United States Department of Agriculture, Agricultural Research Service, Richard B.Russell Agricultural Research Center, 950 College Station Road., Athens, GA 30605 (United States)
- Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alta., T6G 2P5 (Canada)
Adipose tissue contains a large portion of stem cells. These cells appear morphologically like fibroblasts and are primarily derived from the stromal cell fraction. Mature (lipid-filled) adipocytes possess the ability to become proliferative cells and have been shown to produce progeny cells that possess the same morphological (fibroblast-like) appearance as the stem cells from the stromal fraction. A closer examination of mature adipocyte-derived progeny cells may prove to be an emerging area of growth/metabolic physiology that may modify present thinking about adipose tissue renewal capabilities. Knowledge of these cells may also prove beneficial in cell-based therapies for tissue repair, regeneration, or engineering.
- OSTI ID:
- 21043692
- Journal Information:
- Biochemical and Biophysical Research Communications, Vol. 368, Issue 3; Other Information: DOI: 10.1016/j.bbrc.2008.01.113; PII: S0006-291X(08)00191-5; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
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